Insanity X Lives (-X1) Blanaid X Lives

4/17/11

~THE NEVER-ENDING 5 INXTIGATION SERIES~

~COMPLEX PHARMATOPIA~



*Sensitive Material Warning*

X1 On Epilogue:
 

In all candidness, I don't know how to effectively begin this blog entry--no way. I have been seeking for just the right things to say--words escape me. I now realize there is no correct thing to say to usher in just what is going to be expressed here. I do know one thing, that is, if you do read this you will learn things. In my naivety I had no idea anything like this was even remotely possible. 

*Foolish me...

It took several glitches and vanishing documents to bring you this blog entry. Perhaps they were just glitches and this is what took us forever to publish this entry. However, what if they were not? 

I think each blogger puts themselves at risk when they begin to examine and scrutinize coverups very intensely...There are a great many discoveries and revelations. It is our job as we gain knowledge to share it with the rest of the community in the hopes that they can see what the research is about and the points we are attempting to make.  Beyond all of that some things speak for themselves. As we work our way into certain sections of this blog we will allow the research to do the talking for itself. From what is revealed here you may draw your own conclusions. This is extremely sensitive material to digest and process--we do realize this.


"The research does not require any assistance it stands on its own."

Since June 25th, 2009 a myriad of issues and people have adapted altered states, as if they were chameleons--reptiles. I think for the most part what has occurred--thus getting to the bottom of it-- has become more of a complicated web of deceit. Please, do mentally brace yourself for this entry... The more people which seem to become involved in this adds a different dimension.  This thing here has the most dysfunctional dynamic, it is the mother of all cookbooks, and recipe for disaster.  This is a paradigm to an infinite number of slimy characters and snakes. These individuals just keep continuing to emerge from the bottomless pit! It is as if someone opened up a gateway, a deep abyss.

"I don't much care for where this gateway is leading to."
____________________________
SCENE ONE ERECTING AN ANTI-AGING STEROID SCANDAL: 
X1:

The snake got out of its pit! It seems that Applied Pharmacy or Remedy Rx (all of it suspect) is a a drug store. I mean this in the most literal sense of the phrase. Mr. Lopez was subject to disciplinary action for his role as the manager and principle of Applied Pharmacy DBA Remedy Rx. Mind you Remedy is not a licensed wholesaler/manufacturer in the State of Nevada!
During this time Mr. Lopez and agents from his "drug store" became a drug den for expired pharmaceuticals. Beyond that Mr. Lopez could not produce a biennial inventory sheet which keeps an accurate accounting of drug storage within the pharmacy. Therefore, just how many people may have gotten expired and dangerous pharmaceuticals from this "drug store" at current time is unknown.


Among the drugs expired were the following:
  • Progesterone- a steroid hormone

  • Trimix- a drug cocktail used to treat erectile dysfunction

Wholesale drugs distributed to health clinics:

  • Pregnyl- a drug used to promote reproductive health and pregnancy by stimulating ovulation.

  • Ominitrope- a drug used to treat children with growth hormone deficiency
  • Tev-Tropin- a human growth hormone drug. Teva's Tev-Tropin was being used as an anti-aging treatment which is in direct violation of FDA regulations. Tev-Tropin is only supposed to be used for treating children with rare growth deficiencies. It is a criminal offense under federal law to prescribe this drug for any other purpose.
  • Tri-mixis another drug for the treatment of erectile dysfunction
  • Propofol- also known as Diprivan which is used to induce or maintain anesthesia during surgery and different medical procedures. 100% of these purchases which equal 255 vials were sold to Conrad Murray, M.D., of Global Cardiovascular Associates and were shipped to Santa Monica, California.
NEVADA STATE BOARD OF PHARMACY, v. TIMOTHY ANTHONY LOPEZ, R.Ph. APPLIED PHARMACY SERVICES, LLC dba REMEDY RX SEE PAGES 20-72

(X1 Blogger Important Notice At The Time Of Publishing this document mysteriously vanished from the internet.)
NEVADA STATE BOARD OF PHARMACY, v. TIMOTHY ANTHONY LOPEZ, R.Ph. APPLIED PHARMACY SERVICES, LLC dba REMEDY RX SEE PAGES 21-72
  • "Murray bought 130 vials of propofol in 100-milliliter doses and another 125 vials in the smaller dose of 20 milliliters, said Tim Lopez, owner of Applied Pharmacy Services in Las Vegas, where Murray has a clinic. Lopez took the witness stand during the fifth day of a preliminary hearing to determine if there is enough evidence for Murray, who was Jackson’s personal physician, to stand trial after pleading not guilty to involuntary manslaughter. The four shipments of propofol were purchased between April 6 and June 10, 2009, with most of the drugs shipped to the Santa Monica home of Murray’s girlfriend, testimony showed. Jackson died on June 25. Murray also purchased sedatives known as benzodiazpines, Lopez testified. Lopez said he was first contacted by Murray in November 2008 for information about buying Benoquin, a depigmentation cream used to treat the skin disease vitiligo. Jackson was known to suffer from the ailment, but Lopez said Murray told him he had many African-American patients suffering from the disorder."
  • "Lopez said he and Murray lost touch until late March, 2009, when Murray called back and ordered a large amount of the cream. Lopez said he checked Murray’s credentials and had his courier deliver the order to Murray’s Las Vegas clinic. On April 3, Lopez said, Murray called back to say he was happy with the cream and wanted to place another order. “He specifically asked about propofol and saline bags,” Lopez said, recalling that he told Murray he could handle his request. Murray never disclosed who would receive the drugs, Lopez said."
Nevada State Board of Pharmacy Meeting 2010 Applied Pharmacy
The Crowley Files--Kenton Lance Crowley/Aleister Crowley (No Relation):
X1:
Kenton Lance Crowley Poses For His Mug Shot
According to the documentation above it appears as if Mr. Lopez was running a pharmaceutical drug ring. This just gets more sinister in magnitude when you take into consideration this conniving, deceitful, and complex scheme in its entirety. This is a tale of a crime ring to gross proportions! Mind you all of this flew up under the watchful eye of the watchdogs! Yes, the DEA and FDA had not a clue until the damage was rendered--yes they are partially responsible for Michael's death as well in my book. Had this have been regulated as it was supposed to be none of this would have been able to occur.
If you order certain materials to make bombs and plan terrorist attacks are there not red flags which go up? These flags would consist of the FBI & CIA! Why is this not happening by way of the regulatory bodies for complex phamatopia? Prescription drugs are quickly becoming a beacon and all sorts of people are becoming the poster-children for abuse--even our teenagers! A systematic warning and alert system needs to be deployed--the time is long overdue--it is warranted. Some sort of sophisticated tracking system should  be designed to match up pharmacies with well documented bulk orders. There should be a tracking of substances which are not permissible to store in conjunction and this should be done in accordance with licensing and a rigidity of standard! 
In retrospect the same system should be applicable to all patients! We are usually covered under this system by various HMO's. As a direct result the HMO's which police our coverage have systems in place as a cost saving measure not to save a life--please do not get this misconstrued. In this way we are protected from this type of abuse cycle. However, there are people which are able to fly under the radar--undetected because they have no health insurance or lots of money and don't have to answer to any HMO's or co-pay premiums. For whatever is the logic behind this, should these individuals require medicine or any pharmaceuticals they should be subject to the same processing we are via the pharmacy. I state this primarily because there are no HMO's to regulate them! For these are the individuals which have no checks and balances. The system in a pharmacy is only designed to raise red flags for various drug interactions not substance abuse. Pharmacies normally dispense what the prescription from the practitioner states without question.

In worst case scenarios the pharmacy boards are so lenient that often the principal of these pharmacies gets probation. They are often allowed to continue business as usual during or after this probationary period. You will be fully aware of just how bureaucratic and ridiculous this is by the time you have completed absorbing the information contained within this blog. Once you have fully processed this you will then comprehend how out of control this issue has gotten! Where is the regulation?

Now back to Mr. Crowley, to help assist with compounding these drugs which were used in conjunction for unregulated purposes, Mr. Lopez enlisted the help of one Mr. Kenton Lance Crowley. Mr. Lopez knew fully well that because of Mr. Crowley's substance issues and performance record that he would be a suitable candidate for compliance with Mr. Lopez' regime. Mr. Lopez set out to exploit Mr. Crowley for the sole purpose of his prescription drug ring enterprise. And guess what it worked! Now let's rehash Mr. Crowley's pharmaceutical history here and tell me afterward would you hire this guy?
In 1997 it was alleged that Mr. Crowley dispensed the wrong medication to a customer while working as a pharmacist during which he was under the influence of non-prescribed controlled substances after which an accusation was filed against him. The case information is as follows, In the Matter of the Accusation Against Crowley Family Pharmacy and Kenton Crowley number AC 2107. 
Then in 1998 Mr Crowley provided dangerous drugs and sent them out of state with no prescription. Afterward, in August of 1998 Mr. Crowley self-administered Demerol which resulted in his nearly fatal overdose. He was arrested for having in his possession a controlled substance.
In February 1999 Mr. Crowley admitted to the board his actions and was disciplined for his actions. Thus he surrendered his California pharmacist license to the board and agreed at that time that he would not reapply or petition to have his license reinstated for at least three years from the effective date of July 9th, 1999. 
In addition to all of the above in 2003 the Pharmacy Board denied his petition for reinstatement. Further in September of 2004 Mr. Crowley then re-petitioned for a reinstatement which was heard on January 20th, 2005. The Board also found that Mr. Crowley was convicted in November 1998 for providing an addict with a controlled substance. This was a violation of the Health & Safety Code mind you possessing a controlled substance this is another violation of the Health and Safety Code both of which are felonious capers. For these crimes Mr. Crowley was convicted and his sentence was three years of formal criminal probation and a jail sentence for a duration of 120 days.
Moreover, it was also discovered by the Board that Mr. Crowley was indeed convicted on September 23, 1999 for possessing a controlled substance which is also a felony. Mr. Crowley was convicted and was sentenced to 16 months of jail time. Then the Board reinstated his pharmacist license revoked it again however, in the end they placed Mr. Crowley's license on three years of probation with various terms and conditions. One of the conditions of his probation consisted of an order for Mr. Crowley to obey all laws along with several other notable conditions. The Board's decision was effective on April 8th, 2005.
On July 16th, 2007 even after a stipulation of his probation was drug treatment Mr. Crowley plead no contest in the Sonoma County Superior Court for driving with a blood alcohol level of .08 percent or more which is a misdemeanor. The count suspended the imposed sentence and granted him a 36-month conditional release.
Ultimately on February 1st, 2008 the Board revoked Mr. Crowley's license and directed him to pay for the sum of its investigative and enforcement costs for the action. Mr. Crowley was given ample opportunities to straighten up his act and fly right however he did not take advantage of them.
  • "Crowley, who spoke at length with The Enterprise Report in multiple on-the-record interviews in August and September denied any involvement with Dr. Murray or Michael Jackson.  Dr. Crowley initially agreed and then backed out of an on-camera TV interview to talk about his work at the Applied Pharmacy and his knowledge and experience in the world of illegal dispensing of prescriptions.  A spokesman and lawyer for Crowley later telling TER that "he [Crowley] does not wish to be interviewed or dragged into the media frenzy surrounding the death of Michael Jackson." Crowley, a longtime pharmacist, had his California pharmacist license revoked in 1999 for his own drug abuse, prescribing medications to an addict and sending medications across state lines without a prescription (among other legal problems related to his addiction to Demerol ) Crowley has spent time in jail for his drug related crimes.  His Nevada pharmacy license was issued in 2002 on a probationary basis, despite his California problems."
  • "You can read an extensive detailing of Dr. Kenton Crowley's background and legal troubles in a document prepared by the CA Pharmacy Board in October of 2008. Crowley also had a string of problems since he began working at Applied's Las Vegas pharmacy in 2002.  Crowley held the title of “VP of Sales and Scientific Affairs” with the pharmacy.  State of Nevada official records show him associated with the pharmacy until February of 2009, Crowley says he stopped working for the company in July of 2008."
  • In 2007 Crowley was arrested and later convicted of DUI in Sonoma County, CA. Once again in 2008 he was arrested in Elko, Nevada for driving on a suspended drivers license and speeding. The most current arrest, according to a spokesman at the Nevada State Pharmacy Board has not yet been reported to them as required. Dr. Crowley says he stopped working at the Applied Vegas Pharmacy in July 2008 and did not dispense any medications to Michael Jackson via Dr. Conrad Murray before that.  Crowley claims he did not know Dr. Murray and never had any dealings with him. Crowley did tell TER that others in the Vegas pharmacist community who knew Dr. Murray, knew him "as a good doctor". Nevada state pharmacy records show Crowley first received his pharmacist license in 2002 and at that time he was associated with Applied Pharmacy in Las Vegas."
THE ENTRPRISE REPORT

  • "Mr. Chairman and Members of the Subcommittee, I am Robert J. Meyer, M.D., Director of the Office of New Drug Evaluation II, Center for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration (FDA or the Agency). I oversee CDER’s Division of Anesthetic, Analgesic and Rheumatologic Products, a division where many of the scheduled drugs are regulated, including opiate analgesic products. This division works closely with CDER’s Controlled Substances Staff, which coordinates CDER’s activities related to controlled substances and the Drug Enforcement Administration (DEA). I appreciate the opportunity to talk to you today about FDA’s role in regard to controlled substances. FDA is aware and concerned that some consumers are able to obtain controlled substances without a prescription, using the Internet. We recognize the seriousness of this issue and sympathize with the families and friends of individuals who have lost their lives as a result of prescription drug abuse and misuse. The Agency has taken many steps to prevent abuse and misuse of prescription drugs, while making sure they are available for patients who need them. FDA is committed strongly to promoting and protecting the public health by assuring that safe and effective products reach the market in a timely manner and monitoring products for continued safety after they are in use."
FDA Congressional Testimony 2005
Scene Two CONRAD MURRAY & THE RAID:

X1:


Drug Money Confiscated During An Illegal Drug Raid

By now after all of this revelation it was time to locate the battering rams and proceed--take off the hinges--and kick in a few doors. It is evident that a prescription drug ring was going on here according to various news reports. It is apparent that large sums of money were made from the sale of prescription drugs. What makes Mr. Lopez any different from a drug czar?


What is astonishing to me is how this pharmacy was so comfortable in engaging in all of these illicit activities depicted above! There was no conscience for what could be fatal to any of the people which got a hold of all of these compounded drugs--some of which have specific purposes and uses for children--NOT adults! 


This was about money and Mr. Lopez did not care how he got it and what he had to do to get it. Any hint of morality went out the door and so did the possible threat of loosing his license and possible jail time! None of this seemed to put a halt to any of these operations for Mr. Lopez. I presume to him the money was far worth the risks associated with these actions. This includes the loss of a human life!


I just don't comprehend how Mr. Lopez was able to keep this compounding pharmacy afloat for as long as he did. It seems that no one ever questioned the practices of this place. By right the whistle blower or better yet the alarm was due to sound off a long time ago!  Can you hear the warning bells in the distance???
  • "LAS VEGAS — The powerful anesthetic that investigators believe killed Michael Jackson came from a Nevada pharmacy that was raided this week, a law enforcement official told The Associated Press on Thursday. Dr. Conrad Murray bought the anesthetic propofol from Applied Pharmacy Services on May 12 and administered doses from that purchase to Jackson in the hours before his June 25 death, the official said. Authorities are focused on propofol as a central element in Jackson's death at age 50. The drug is usually administered by anesthesia professionals in medical settings to render patients unconscious for medical procedures, but Jackson had been using it in his home. Drug Enforcement Administration agents and police served a search warrant Tuesday and took evidence showing Murray legally bought the propofol from the store, said the official, who requested anonymity because the investigation is ongoing. The warrant lists two lot numbers for the drug, made by two different manufacturers, and both were found in Jackson's rented Beverly Hills mansion after his death, the official said."


  • "Tuesday's warrant filed in Clark County District Court shows detectives hoped to find records including credit card receipts, shipping orders or mailing lists showing that Murray or his employees bought prescription medications "including but not limited to" propofol on May 12. A woman who answered the phone at Applied Pharmacy Services hung up without commenting. After a 90-minute search, investigators seized only paperwork from the pharmacy, the warrant shows. No details were provided. The search came weeks after police and DEA agents served warrants and removed records and items from Murray's Las Vegas home and medical office. And on July 22, authorities seized computer hard drives, medical equipment invoices, phone records and other items from Murray's Houston clinic and a rented storage unit.
____________________________
Scene Three Applied Bankruptcy--Shut Em' Down:

X1:


What doesn't come out in the wash must come out in the rinse. Eventually what you do in the dark must come out to see the light of day. Most reptiles like to slither around undetected. You see all of the shady dealings with Conrad Murray got these people along with Mr. Lopez even more notoriety and publicity! Yes, I think that is wonderful actually. Light needs to be shed on the fact that this pharmacy and its principal violated several laws. Michael is gone because of this pharmacy and as a direct result of Mr. Lopez, Conrad Murray, and many others playing loose with the law!

I presume after all the legal fees were charged--the invoices were printed itemizing the blow by blow costs for their reckless disregard; that meant the bills were then due!  As you can see from the Board documents each time Mr. Lopez or Mr. Crowley went before them they required attorneys. I would think that the legal representation which Mr. Lopez had retained kept him from doing a prison stint. Mr. Crowley on the other hand was not so lucky.

Besides that any educated individual, with any common sense which was engaged in any illegal activity with this pharmacy immediately distanced themselves and severed ties with a ten foot pole! So that meant no more drugs to sell to providers. Please do not tell me that criminals are not educated. These are doctors and pharmacists which we are discussing here.


Above all of that this pharmacy finally acquired the interest of the DEA and the Boards so now they had the authorities breathing down their necks and this was not conducive at all to the drug ring's daily activities of selling medications without prescriptions as a wholesaler!


In all candidness I cannot state that I am not literally enthusiastic to see them file for bankruptcy according to the tabloids in less than 90 days. Or then again on second thought is Applied Pharmacy about to file that bankruptcy right in time for Joe Jackson's law suit as Applied Pharmacy & Conrad Murray are both named in it? You can't get water from a rock now can you? If they were compounding drugs what makes any of us think they are not capable of conspiring to squirrel-stash/tuck away & hide funds?

My major concern here is that Mr. Lopez is not allowed to wander from state to state like a nomad in search of the next place to set up shop and expand his lucrative "drug empire". Where there is a market there will always be some snake around to exploit it and supply the demand. This is the sad reality of the situation here with snakes like Mr. Lopez. The various Boards and authorities need to apply  the breaks; a permanent red light on this guy--if need be they can stamp permanent a stop sign on his forehead.  Mr. Lopez needs a serious time out!
____________________________

  • "According to court documents obtained by TMZ..."Applied Pharmacy has been shut down by the State of Nevada and will file Bankruptcy in 90 days."

Dr. Murray Propofol Pharmacy Shut Down

  • "Dr. Conrad Murray's go-to pharmacy for propofol supply is going out of business. Murray, who is accused of overmedicating pop superstar Michael Jackson with the sedative, was a frequent buyer at Las Vegas-based Applied Pharmacy Services. Now, TMZ.com says the State of Nevada is shutting it down. According to court documents obtained by the celebrity website, Applied Pharmacy will file for bankruptcy in 90 days. The pharmacy is on record for shipping multiple  packages of the powerful anesthetic to Murray in the months leading up to Jackson's 2009 death."
  • "Meanwhile, the pharmacy that supplied Dr. Murray with massive amounts of Propofol for Michael Jackson is being shut down by the State of Nevada, according to TMZ, and will file for bankruptcy in 90 days. Applied Pharmacy shipped multiple packages of Propofol to Murray at his girlfriend’s Santa Monica address in the months before Jackson died."
  • "The lawsuit against Murray seeks unspecified damages. Joe Jackson also names Las Vegas’ Applied Pharmacy services in the lawsuit. Court records show the pharmacy sold Murray excessive amounts of propofol in the weeks before Michael’s passing in June 2009. According to the autopsy report, Michael’s death was caused by acute propofol intoxication."

____________________________
Scene Four Ensuing Chaos & Confusion:
BX: 




Starting with the news that Michael Jackson had died on June 25, and during the days following June 25, there was a lot of confusion surrounding the events at Holmby Hills. Many articles were published--presenting latest developments, news, speculations, and rumours. The shock about Michael's passing was deep, and it was a time when hardly anyone could follow the various developments. The preliminary hearing in January brought back memories, and not just that. New details emerged, when e.g. the security guards testified that Conrad Murray had told them this was the first time he did CPR. Or Sade Anding - whose testimony seems to place the time when Conrad Murray got aware something was wrong with Michael at about 12 PM Los Angeles Time--although I am still having issues with the time zone question. No one had heard of Ms Anding before which is, in view of all those leaks we have seen, an amazing fact.

The situation back in June 2009 was very different from the situation we are facing today. These days, with the jury selection and thus the trial of Conrad Murray having started, there is one topic which dominates the news and everyone seems to be focused on. We could call this story the Propofol story. The question what caused Michael's death has been settled it appears--an amount of Propofol administered at such quantity (and probably such speed) that it caused Michael's breathing to stop (respiratory arrest) followed by a cardiac arrest. The question who administered this amount of Propofol, however, is disputed. For some, there is no doubt Conrad Murray is responsible; Conrad Murray himself denies this vehemently and keeps repeating he administered such a small amount that this could never have led to a respiratory arrest and thus could never have caused Michael's death. This dispute is what the media and the parties are focusing on. Recently, the various women Conrad Murray was talking to over the phone on June 25 began to play a more prominent role. As a by note, it seems that the focus is taken away from the circumstances of the actual administration (how much, when, who) and put on the lack of attention, i.e. the lack of care and personal monitoring--I wonder why. It is the prosecution who brought this up now--does this mean they came to the conclusion that they cannot prove how this amount of Propofol was administered? Think of the disaster with the last witness they called during the preliminary hearing...

Also, recently, the name of another drug appeared which was very prominent in the early days--although in a somewhat different context: Demerol.

_______________________


  • "According to TMZ, lawyers for Dr. Conrad Murray just filed legal documents claiming Klein was fueling Jackson’s drug dependency with scores of Demerol and another powerful narcotic. According to the documents, in the 3 months before Jackson died, Dr. Klein had given Jackson no less than 51 Demerol injections."
(March 22, 2011)
Dermatologist Fueled Demerol Addiction
_______________________



BX:
 

Even before Michael had been removed from UCLA his death got linked to prescription drugs. Brian Oxman was outside the hospital, giving the first of many interviews related to Michael and the circumstances of his passing.
Whatever made Brian Oxman make these statements at this point of time--with these interviews Michael's alleged use of prescription drugs, or alleged dependency, was made known to the wider public a few hours after Michael had died

In these early days, however, the prevailing story was a different one than the one that is prominent now. This first and early version did not just vanish but got replaced by a different story--focusing on a different drug. Following Brian Oxman's statements on June 25, there were countless articles related to Michael's use of prescription drugs--which centered on Demerol, the drug that recently resurfaced.

________________________

  • "Michael Jackson’s cardiac arrest may have been the result of using Demerol, a powerful synthetic narcotic drug. Reportedly Michael received an injection of the painkiller before his breathing slowed and he suffered cardiac arrest."
http://www.emaxhealth.com/1020/82/31955/painkiller-demerol-may-have-caused-michael-jacksons-death.html

  • "Michael was receiving pain treatment, related to performance injuries, by using Demerol, a narcotic drug similar to morphine that carries a high potential for abuse. According to Brian Oxman, a Jackson family lawyer and spokesman, Michael Jackson had been struggling with pain. Oxman told CNN, "I can only tell you that this is not something which has been unexpected."
http://www.emaxhealth.com/1020/82/31955/painkiller-demerol-may-have-caused-michael-jacksons-death.html
  • "Autopsy results, including toxicology screens will tell us if Michael Jackson is another victim of drug abuse from Demerol or other narcotics or sedatives. Until autopsy and toxicology reports are completed, speculation undoubtedly will ensue as to whether Demerol caused Michael Jackson’s cardiac arrest and death."
http://www.emaxhealth.com/1020/82/31955/painkiller-demerol-may-have-caused-michael-jacksons-death.html

  • "Family members said Friday that Jackson received a massive dose of Demerol shortly before he went into cardiac arrest. Any doctor who legally administers the drug must be certified to do so. The doctor did not sign the death certificate, which is protocol for a death that occurs under the watch of a physician. If the doctor does not provide the police with the details and circumstances surrounding the death and does not sign the death certificate, the case will be transferred to the coroner’s office, where it will be investigated as a homicide."
http://www.foxnews.com/entertainment/2009/06/26/doctor-jackson-believed-cardiologist/
  • "Jackson's former video producer said the pop star, who died Thursday at age 50 from cardiac arrest, had a "20-plus year" addiction to the painkiller Demerol, as well as to a cocktail of other drugs, such as Oxycontin. Jackson became so addicted that the video producer and other close associates tried to stage an intervention in 2003, but it derailed because of a world tour, said Marc Schaffel, who was named as an unindicted co-conspirator in Jackson's 2005 child molestation trial. Schaffel's accusations were backed by a senior law enforcement official who told ABC that Jackson was "heavily addicted" to Demerol and received "daily doses" of Oxycontin. During the 2005 child molestation trial, the judge ordered prosecutors to return hundreds of items that were not deemed "contraband," according to The Associated Press at the time. Those items included syringes, the drug Demerol and prescriptions for various drugs, mainly antibiotics, that were in different people's names."Prior to Jackson's arrest and the raid on his Neverland ranch, some of the star's doctors talked about staging an  intervention, according to Schaffel."
http://abcnews.go.com/Health/MichaelJackson/story?id=7938918&page=1
  • "We actually didn't do it, but we were talking about it when we were getting ready to leave on a six month trip," he said. "We had spent Christmas and New Year's at Elizabeth Taylor's place in the Swiss Alps and we were headed to do an award show in German and France and South America."
  • "The misconception is talking about people enabling him," said Schaffel. "About 90 percent of the people had nothing to do with the drug use. His regular doctors didn't give him drugs." 
  • "Michael Jackson’s friend and dermatologist, Dr. Arnie Klein, has admitted to giving the singer Demerol. The Jackson family made a list of doctors that they suspected may have given the singer prescription drugs, and Dr. Arnie Klein was on it. Although the results of the toxicology tests have not yet come in, this is one of the pain killers that Michael Jackson was thought to have been overmedicated with at the time of his death."
(July 9, 2009)
http://www.examiner.com/celebrity-headlines-in-philadelphia/dr-arnie-klein-admits-to-providing-michael-jackson-with-demerol
________________________


BX:


Many fans object to the notion Michael could have been addicted to prescription drugs, specifically pain medication. However, various members of Michael's family came forward and made statements to this effect. From the last quote listed above you can see that his family provided a list of physicians to LAPD right after June 25 in relation to overmedicating Michael with prescription drugs. And most notably Janet came forward and talked about the issues her brother had with prescription drugs. I wonder what her motives could be to make these statements on national TV when they would not be true.


November 18, 2009
(April 2, 2010)
  • "While many of the people who worked with Michael Jackson on his "This Is Is" concerts expressed surprise at his struggles with drug addiction, sister Janet Jackson told ABC News that she and her family were well aware of her brother's demons. In fact, Jackson said that she and her family reached out several times over the years to confront Michael about his drug problem and stage interventions, to no avail."
http://www.mtv.com/news/articles/1626526/janet-jackson-michael-may-have-been-denial-about-drug-problems.jhtml
  • "In a candid chat with TV host Oprah Winfrey, which aired in America on Friday (02Apr10), the R&B star said, "There was a moment where I had to actually walk away, I couldn't take it; I was just so overwhelmed with emotion... It was just too much for me to handle. "You have to understand too that a lot of the relationships I've been in, they've (boyfriends) had issues with addiction. So I know something about it. It's difficult when you see it and you recognise it." Janet told Winfrey the Jacksons staged "several" interventions - but brother Michael, who died last summer (09) following a drug-related cardiac arrest, refused to accept he had a drug problem."
http://www.contactmusic.com/news.nsf/story/janet-struggled-with-michael-jacksons-family-interventions_1137735
_________________________


BX:


On the other hand, you have people like Lou Ferrigno stating Michael was in good shape and showed no signs of pain or drug use. However, if there had been no long standing and current prescription drug issues, again, what would be the motives for people, including members of his family, to make statements like these on national TV? On the other hand, what would be the motives for people who say there were no signs of any issues?





While the Demerol story produced countless news, the person who allegedly was with Michael when he died, a physician, went missing.
________________________
  • "The "personal physician" who was in Michael Jackson's home when the King of Pop died of a massive heart attack is believed to be Dr. Conrad Robert Murray, a cardiologist with offices in Texas, Nevada and California. Police towed a silver BMW from the driveway of the home in Holmby Hills, Calif., Thursday evening. The car belongs to a Texas woman, Susan Mary Rush, who is Murray's sister, a law enforcement source told FOXNews.com."
(June 26, 2009)
  • "Rayner did not divulge the doctor's name, but she said he was briefly interviewed at the scene on Thursday, and that investigators wanted to speak with him further to get a more detailed statement. She said the doctor has not contacted authorities to retrieve his car from impound. "It's not like he's missing in the sense that someone has filed a missing person report, but he is someone the detectives would like to eventually talk to. It's standard procedure. But no, I don't know where he is," she said."
(June 26, 2009)
http://www.foxnews.com/entertainment/2009/06/26/doctor-jackson-believed-cardiologist#ixzz1I0PYA31y
  • "And Reverend Jackson is urging Murray to be completely honest about the last few hours of the star's life - because his family and his fans need to know what really happened. He says, "Any other doctor would say, 'Here's what happened in the last hours of your child's life.' "When did the doctor come? What did he do? Did they inject him, if so with what? Did he inject Michael once or twice with Demerol? (There are) questions of substance that will not go away until they are answered. "He owes it to the family and to the public to say: 'These were the last hours of Michael's life and here's what happened."
(June 26, 2009)
http://www.contactmusic.com/news.nsf/story/jesse-jackson-demands-answers-from-doctor_1107963
________________________


Scene Four & 1/2 Murray Pulls a Houdini/The Vanishing Act:

BX:




On June 27, after about 2 days with the Demerol story proliferating, Conrad Murray resurfaces and meets with LAPD, accompanied by his lawyers. Where was he between his disappearing act at UCLA and resurfacing act on June 27? Who did he have contact with? If we talk about a cover-up, would it not be highly interesting to get a timeline for his whereabouts after he was allegedly last seen at UCLA? It seems a lot of emphasis is placed on the events that took place *before* the ambulance arrived at Holmby Hills. We would learn a lot about what happened, however, if we found out more about the whereabouts and actions of people after the ambulance had left Holmby Hills--not just those of Conrad Murray. What was he doing during the 2 days until he resurfaced in Los Angeles?
_______________________
  • "Murray handed himself over to police on Saturday afternoon (27Jun09) to explain the circumstances surrounding the star's tragic demise - amid swirling rumours Jackson had abused prescription medicines. A statement from the Los Angeles Police Department reads, "Dr. Conrad Murray, the physician who was with Michael Jackson at the time of his collapse, voluntarily contacted the Los Angeles Police Department. Detectives assigned to Robbery-Homicide Division met with Dr. Murray and conducted an extensive interview. Dr. Murray was cooperative and provided information which will aid the investigation."
http://www.contactmusic.com/news.nsf/story/jesse-jackson-demands-answers-from-doctor_1107963
_______________________


BX:


On June 27, Conrad Murray sits down with LAPD detectives and does what Jesse Jackson had asked him to do - he tells them what happened in the last hours of Michael Jackson's life. The details of what Conrad Murray told the detectives can be found in their affidavits which are attached to the relevant search warrants, e.g. for Applied Pharmacies in Las Vegas.
Account of Conrad Murray's statement on June 27 (Affidavit Picture 1)
Conrad Murray's resurfacing and statement to LAPD detectives marks a turning point. Following his Saturday statement, another search warrant was requested, issued and then executed on June 29 which was the following Monday. Conrad Murray's story centered on a different set of drugs than what had been discussed in the media. He actively denied having administered Demerol or other drugs that had been mentioned in relation to Demerol, notably Oxycontin.
___________________________

 "Edward Chernoff also said Dr. Conrad Murray never prescribed or gave Jackson the drugs Demerol or OxyContin. He denied reports suggesting Murray gave Jackson drugs that contributed to his death. ... Dr. Murray has never prescribed nor administered Demerol to Michael Jackson. Not ever. Not that day. Not Oxycontin either for that matter."

Chernoff Caims Murray Never Prescribed Demerol
____________________________

Account of Conrad Murray's statement on June 27 (Affidavit Picture 2)
During the first search on June 25/June 26 (apparently, there was an onsite investigation carried out on June 25 with the investigators arriving at Holmby Hills shortly after 7 PM while the relevant search warrant was issued on June 26), Ms. Fleak, the employee the coroner's office had entrusted with the on premises investigation into Michael Jackson's death, had found a small, empty  bottle of Propofol on the floor below the bedside table as well as a bottle of Flumazenil (see forms 3A of the coroner's report for the drugs found; there are 3 forms 3A).
Account of Conrad Murray's statement on June 27 (Affidavit Picture 3)
On June 29, Ms. Fleak finds more drugs in the closet of the bedroom where the paramedics had treated Michael, including several bottles of Propofol. These drugs were not prescribed to any specific patient; altogether, according to Ms. Fleak's report, she found 3 100ml vials and 8 20ml vials. This find on June 29 put the spotlight firmly on the Propofol.


As a result of these developments, the Demerol story starts to disappear and is replaced by the Propofol story. Not even the benzodiazepines discovered by Ms. Fleak on June 29 would be playing a similarly prominent role. Conrad Murray and the Propofol got the focus, not just in news articles but also in forums, blogs, websites and social media pages run by fans and supporters.
______________________
Scene 5 Nurse Shady:

BX:


However, parallel to the surfacing, or resurfacing, of Conrad Murray on June 27, someone else surfaces. And this person gets the media spotlight on June 29, the same day the Propofol bottles were discovered in the bedroom where Michael Jackson was treated by the paramedics. The name of this person is Cherilyn Lee. Actually, her full name is Cherilyn Cammon-Lee. At times, she is referred to as Dr. Cherilyn Lee or Dr. Cherilyn Cammon-Lee, and she certainly is referred to as holding a PH.D. on her website. Conrad Murray mentions her during his meeting with LAPD detectives on June 27:

________________________________

  • "At one time MURRAY noticed and inquired about injection marks on JACKSON's hands and feet. JACKSON stated that Doctor CHERILYN LEE had been giving him a "cocktail" to help him. MURRAY believed the cocktail to be a PROPOFOL (DIPRIVAN) mix. MURRAY also recounted how sometime between March and April of this year, JACKSON called him in Las Vegas and asked him to call Doctor DAVID ADAMS and arrange for Doctor ADAMS to give JACKSON PROPOFOL (DIPRIVAN). MURRAY did as JACKSON asked and arranged for Doctor ADAMS to treat JACKSON."
Affidavit Picture 3
______________________________

BX:


Here is Cherilyn Lee on CNN breaking the story on June 29 which was aired on CNN at 4 AM PT--when was it recorded? Recall, and I think the chronology is important here, that Conrad Murray was talking to LAPD on June 27, and that it would be clear generally that an investigation would be taking place. Following the videos, you will find some information on her background.


______________________________

  • "Dr. Cherilyn Cammon-Lee obtained her education and training as a Physician Assistant and Nurse Practitioner in 1982 at Charles R. Drew University of Medicine and Sciences and received her Ph.D. in Holistic Medicine from Clayton School of Natural Health. Her credentials also include certification as a Licensed Clinical Nutritionist (Southwest College 1977), Auriculotherapist and certification in Energy Medicine and Quantum Reflex Analysis. She is currently enrolled at Trinity College of Natural Health in the Physician of Naturopathic Medicine Program."
http://www.nutrimedhealthcare.com/html/nmdrlee.htm


  • "The American College of Holistic Nutrition was founded in 1980 by Lloyd Clayton Jr. In 1997 its name was changed to Clayton College of Natural Health. Clayton College of Natural Health never had educational accreditation from any agency recognized by the U.S. Department of Education or the Council for Higher Education Accreditation. Several state education agencies specifically list Clayton as unaccredited, among them Oregon, Texas, Michigan, and Maine. Degrees issued by Clayton may not be acceptable to some employers or institutions, and use of degree titles granted by Clayton may be restricted or illegal in some jurisdictions."
http://en.wikipedia.org/wiki/Clayton_College_of_Natural_Health
  • "Dr. Cherilyn Lee is Founder and CEO of Nutri-Med Intergrated Healthcare Center, Inc. (NMIHC). NMIHC is a Comprehensive Alternative Family Healthcare Center that offers alternative medicine and a more holistic/integrated approach to dealing with common diseases and ailments."
http://www.nutrimedhealthcare.com/html/nmdrlee.htm 
  • "At NMIHC, Lee practices intergrated healthcare. She specializes in treating: high blood pressure and diabetes; pelvic exams for women including PAP smears; PSA testing and prostrate examinations for men; pediatric healthcare; IV Vitamin and Chelation treatments; and, IV Treatments for drug abuse and other medical/nutritional conditions. Hepatitis treatments are also available to assist the healing process. NMIHC specializes in: Bio-Energetic Meridian Assessment (BEMA); Energy Medicine; Hyperthermia Full Body Treatment; Comprehensive Nutrition/Diet Evaluation; Quantum Medicine; Pain Management Auriculotherapy; and, Acoustic Cardiograph (ACG). The latest addition to the clinic is the Digital Arterial Pulsewave Analyzer which clinical applications includes reflects arterial wall function/stiffness and indicator of cardiovascular disease."
http://www.nutrimedhealthcare.com/html/nmdrlee.htm


______________________________________
 

BX:


If you watch these videos, and specifically the last one with John Roberts, you notice the heavy focus that is put on Michael's sleeping issues, insomnia which explains his need to find a remedy for this. Here, you have the whole story, complete with a motive--insomnia--which now gradually replaces the Demerol story.

 

Strikingly, Conrad Murray stated he believed the cocktail Michael said Ms. Lee had administered to be consisting of Propofol. Ms. Lee now is taking up this very same word--just that it was "Myer's Cocktail", a purportedly harmless nutrional supplement--administered intravenously, however.
______________________________________
  • "The Myers cocktail, an intravenous blend of vitamins and minerals, has become increasingly popular in the less-traditional medical world in recent years. It went public a few days ago when nurse Cherilyn Lee, who specializes in nutritional counseling, said she had given Michael Jackson an intravenous blend of vitamins and minerals called a Myers cocktail. ... The concoction, based on one created by physician John Myers of Baltimore, includes magnesium, calcium, several B vitamins and vitamin C."
The Myers Cocktail
______________________________________

BX:

How did Cherilyn Lee meet Michael? Interestingly, Ms. Lee volunteers this bit of information... Her story of how she met Michael is astonishingly similar to the story of how Conrad Murray got to know Michael as e.g. described in Joe Jackson's wrongful death lawsuit as filed on November 20, 2010 (pages 3-4).
______________________________________
  • "Cherilyn Lee: well I met him in January. And because someone called me and said his children had a runny nose and a little cough and could I come out to the house and see them. And because it was a referral person he felt very comfortable. And so when I arrived at the house I saw three children. And actually I love working with children and I kind of set something up for them some vitamin c and, you know, as a practitioner I listened to their lungs to make sure they were clear and went ahead and did the routine physical exam and everything. And after I finished with the children and had given them some vitamin c that they had, you know, the vitamin c powder and a couple of other things, it's a homeopathic; they told their dad they were feeling a lot better. So he looked at me and said what else do you do? And so I said well I help people, you know, when they want to very more energy. And he said, oh, well, okay, that's really good. And so we start taking it from there and I try to find out why is it you don't have any energy? And just went through the whole course of, you know, not that day. He asked me if I could come back the following day. So I went and drew some blood, maybe you're anemic or maybe it's this or that, but let's not second guess anything. I did full lab work. A full work-up on him. Then I told him from there that nutritionally we could get you set up."
(June 30, 2009)
http://ac360.blogs.cnn.com/2009/06/30/transcript-of-cherilyn-lee-interview/
_____________________________________

BX: 

Also, Cherilyn Lee was a lifelong fan of Michael Jackson. Combine what she is saying in this video with the statements following it:


Please view from Mark: 3:00
_________________________
  • "Murray immediately made it clear he did not give Michael the two drugs most people were talking about – Demerol and Oxycontin. But now, according to a law enforcement official, Murray has admitted that he did inject Jackson with Diprivan on the morning he died. Today, in a new interview, nurse Cherilyn Lee says she turned down Jackson’s request for the powerful drug, and revealed to Access Hollywood how sleep became something the pop star desperately wanted. “Mr. Jackson did not present himself as a drug addict and from January to April, I didn’t see that in him,” Lee told Access. “Even when it came to the Diprivan, he was looking for something that was going to help him sleep.” Lee said Jackson was not addicted to drugs. He only wanted to sleep. So at Jackson’s request, Lee sat in his bedroom with him and watched him as he tried to sleep. “The night I stayed with him… He said, ‘I want to you to see how I sleep, ‘cause I want you to see that I don’t fall asleep. Or I fall asleep it takes awhile, but then I wake up after a couple hours.’ And that was before he started talking about the Diprivan,” she recounted. “He said, ‘Once it hits my veins, I’m knocked out. And I wake up the next morning I feel good, I’m full of energy,’” Lee continued. “He was very excited about it – ‘Please find me someone.’” Lee would not and her warnings that Diprivan could cause death went unheard by the pop star."
______________________

BX:

The above interview with Access Hollywood was done a month after her initial statement to CNN. Most important here is her statement that Michael did not appear to be addicted to drugs and that all he wanted was sleep. On the other hand, she made Michael aware of the dangers of Propofol so if he had not known these facts before, he appears to have known them after Ms. Lee discussed them with him.
______________________

  • "Cherilyn Lee: it is a - you know, still I don't want to go into a whole lot of detail with it. It’s in the PDR, I sat down with Michael and I said I actually left him that day because he didn't understand. He kept thinking this was safe. I went all the way back to my office, went back to him and said, look. This medication is not safe. I don't know who is telling you this is safe. It isn't. He said I just want to get some sleep. You don't understand. I want the IV when it drips in my hand; I want to be able to be knocked out and go to sleep. And this was the very first time, even though we had discussed this before that I told him, you know, it is so painful because I actually felt it in my whole spirit. I said if you take that, you know, you want to be knocked out, and I’m so sorry but if you take this you might not wake up."
(June 30, 2009)
http://ac360.blogs.cnn.com/2009/06/30/transcript-of-cherilyn-lee-interview/
_____________________________________


BX:

Let me briefly wrap up: Within a few days, the Demerol story started to disappear and was superseded by the Propofol story, as detailed by Conrad Murray and Cherilyn Lee and highlighted as a result of the search on June 29. At least three different sources were quoted by various media carrying the Demerol story:

- TMZ / alleged source: family members
- ABC / alleged source: senior law enforcement (+ Marc Schaffel)
- Sun / alleged source: UCLA staff


Finally, I am wondering... Cherilyn Lee travelled all the way from Los Angeles to Las Vegas to attend the premiere of This Is It which was endorsed by Joe Jackson. Did she pay for the all-inclusive tickets?
Nurse Lee Attends The This Is It Premiere In Vegas



I am also wondering when I see those two quotes one after the other:
 
_____________________________________
  • "At NMIHC, Lee practices integrated healthcare. She specializes in treating: high blood pressure and diabetes; pelvic exams for women including PAP smears; PSA testing and prostrate examinations for men; pediatric healthcare; IV Vitamin and Chelation treatments; and, IV Treatments for drug abuse and other medical/nutritional conditions."
http://www.nutrimedhealthcare.com/html/nmdrlee.htm
  • "In the months leading up to his London performances, Jackson told his sister that he was on a six-month detox to prepare for his comeback, but LaToya says she had other suspicions."
http://www.people.com/people/package/article/0,,20287787_20289401,00.html
 ________________________
BX:

And I leave you with this - those six months leading up to the London shows would start in January, when Ms. Lee surfaced in Michael's life.

________________________

Appendix
CNN Campbell Brown Transcript Nurse Cherilyn Lee 


  • "Cherilyn Lee: well, I received a call, I was in Florida. And unfortunately, I was actually in the hospital myself in the E.R. in Florida. And I received the call and I could hear Mr. Jackson in the background saying please have her come see me now. Can she come now? And the person in on the other end, which I know the person, but I’d prefer not to give out their names. Because they know me quite well said that Mr. Jackson really, really needs you. He is experiencing - they told me the symptoms and I said that is very serious, you need to go to the hospital. Unfortunately I’m not in town so I cannot come and see you. But you need to go to the hospital. I’m very - I was really afraid because of the symptoms he was telling me. the symptoms were one side of his body felt cold and one side of his body felt hot. Well, that meant - it could have meant a couple of things. It could have meant something going on in the nervous system, or something cardiovascular, but more than nervous system because of the brain itself. and I had already gone through - I think this is why he was reaching out for me Sunday because I had already about three months ago went through all of the symptoms this medication that he wanted that his doctor told him and I don't know who his doctor is. His doctor told him that this was safe."
  • "Cherilyn Lee: he was asking me for the drug.  And he was asking me about it three months ago and I said I don't know what that is so I excused myself from where he was, and I made a call to a friend who was a physician and I said what is? At first I thought he was mispronouncing it. Are you speaking of something else? He said no. and when I spoke with the physician he said that is a very - you do not - he asked me, he said who is asking about this drug? This is a medication you only really give in ICU."
  • "Cherilyn Lee: it is a - you know, still I don't want to go into a whole lot of detail with it. It’s in the PDR, I sat down with Michael and I said I actually left him that day because he didn't understand. He kept thinking this was safe. I went all the way back to my office, went back to him and said, look. This medication is not safe. I don't know who is telling you this is safe. It isn't. He said I just want to get some sleep. You don't understand. I want the IV when it drips in my hand; I want to be able to be knocked out and go to sleep. And this was the very first time, even though we had discussed this before that I told him, you know, it is so painful because I actually felt it in my whole spirit. I said if you take that, you know, you want to be knocked out, and I’m so sorry but if you take this you might not wake up."
  • "Cherilyn Lee: What happened was, I was actually at the hospital myself. I was in the emergency room in St. Petersburg. And was being admitted myself. So I tried to call back later and I could not reach anyone. And I was - I was in Florida for a couple of days there. When I arrived back in L.A., I still was trying to reach, you know, I could not reach anyone. So I didn't know whether or not he had gone".
"Campbell: did you go to the authorities with any of this?"
"Cherilyn Lee: no"
  • "Cherilyn Lee: well I met him in January. And because someone called me and said his children had a runny nose and a little cough and could I come out to the house and see them. And because it was a referral person he felt very comfortable. And so when I arrived at the house I saw three children. And actually I love working with children and I kind of set something up for them some vitamin c and, you know, as a practitioner I listened to their lungs to make sure they were clear and went ahead and did the routine physical exam and everything. And after I finished with the children and had given them some vitamin c that they had, you know, the vitamin c powder and a couple of other things, it's a homeopathic; they told their dad they were feeling a lot better. So he looked at me and said what else do you do? And so I said well I help people, you know, when they want to very more energy. And he said, oh, well, okay, that's really good. And so we start taking it from there and I try to find out why is it you don't have any energy? And just went through the whole course of, you know, not that day. He asked me if I could come back the following day. So I went and drew some blood, maybe you're anemic or maybe it's this or that, but let's not second guess anything. I did full lab work. A full work-up on him. Then I told him from there that nutritionally we could get you set up."
"Campbell: right. And his doctor was also working with him presumably yet? Dr. Murray."
"Cherilyn Lee: I don't know. I didn't see anybody. I didn't see anybody in January. February, March, there was a time he did go to London, so -he was out. But I never heard of a doctor, I never did see anyone."
____________________________

Scene 6~


Attempting A Valid Explanation For Arnold Klein's Actions:


X1:

I am always embarking on a quest for extensive information. During one such session I discovered something extremely complex. In my opinion this is sensitive information which required some highlighting and exposure. No one has ever really been willing to discuss one fact in our community. Michael was actually receiving Demerol via Arnold Klein. We all know by now that Dr. Arnold Klein was administering Demerol to Michael for a host of procedures. Arnold Klein has made us fully aware of this for the record. Furthermore, he has stated himself that some of these procedures were very excruciating thus they required the help of painkillers to ease any discomfort which Michael may have experienced as a direct result of them. Moreover, according to Dr. Klein there were many microscopic injections done during these procedures which aided in the process.

Michael Leaving Arnold Klein's Office:





It is now factual that Michael was given Demerol beyond a shadow of a doubt. Although this was not listed as the official cause of death for Michael--it is well documented that in the weeks before Michael's death Dr. Klein administered this drug to him. In all actuality this may very well be the one key we are all missing here! This would be while embroiled in our denial to associate Michael with any painkilling medications. Moreover, the information of Michael having issues with painkilling drugs is well documented. Many did not wish to acknowledge that he was receiving this drug. To some people in our community this subject is shameful thus taboo--meaning it is not open for discussion. In some capacity it is viewed that this would have a negative connotation. Many felt it would damage the Conrad Murray trial in some capacity.

According to claims made by Arnold Klein he helped Michael beat this dependency which he did not specify; however, not once--but twice, and he gives Michael Demerol afterward???! I also think it is important to add that Arnold Klein stated that when the estate was billed for past medical procedures their was no way of knowing the amounts administered per injection! Then Michael developed a tolerance to this drug and he started to reduce him! Then he speaks in a double tongue, and talk by stating Michael had addiction issues. Directly afterward Arnold Klein then changes his story which is full of major contradictions again! He then states that he did not witness any withdrawal symptoms!  My guess is one would not if they are providing the substances to a patient on a continuous basis.

TMZ Full Arnold Klein Interview: 





Now here come the questions--valid ones! 
1. What possessed Arnold Klein to administer this drug to Michael knowing that he had a prior dependency to pain killers before?
2. Weren't there other pharmaceutical painkilling options (non-narcotic) which he could have explored with Michael? See ON-Q PainBuster Just One Example
3. Now if this is to be the case here is it safe to say that if Michael was consistently being injected with Demerol that this may have posed a tolerance issue?
Now if you assess the time line you can see clearly that Michael was being given this drug Demerol before his tour.

The drug Demerol has an addictive warning on it therefore this is possible! Here read the warnings for yourself below:
____________________________

Demerol Warnings:
  • Demerol is an opioid agonist and a Schedule II controlled substance with an abuse liability similar to morphine.
  • Demerol can be abused in a manner similar to other opioid agonists, legal or illicit. This should be considered when prescribing or dispensing Demerol in situations where the physician or pharmacist is concerned about an increased risk of misuse, abuse, or diversion.

Michael Leaving Dr. Klein's Office:
  •  "So for the last few months we've been catching Michael Jackson leaving a medical building in Beverly Hills. Now we know who Jackson has been seeing.Jackson has been going to the office of Dr. Arnie Klein -- dermatologist to the stars -- and he's been going there several times a week lately. Klein and M.J. have a long history together. Klein has treated Jackson's Vitiligo -- a pigmentation disorder."
  • "We're looking at some documentation that Dr. Klein has agreed to provide to us," Winter said. A lawyer for Klein said he met with Winter inside the doctor's office, but an employee in the office said the doctor was not there.

Run For Cover It's A RAID Mickey IS NOT Fine:

The Mickey Fine Pharmacy Raid
  • "32062, BEVERLY HILLS, CALIFORNIA, Tuesday, June 30, 2009, Los Angeles based dermatologist Arnold Klein's office in Beverly Hills, which was visited by Michael Jackson just one week before he died. Situated next door to the office is the Mickey Fine pharmacy, where Jackson settled a bill for $100,000 for prescription drugs after being sued by the pharmacy's owners.
  • "Thursday saw the Los Angeles County Assistant Chief Coroner at Dr. Arnold Klein's office, ostensibly to pick up more medical records. Friday saw the DEA raid the Mickey Fine Pharmacy next door to Dr. Arnold Klein's office. Coincidences?"
  • "The July search warrant affidavit that officials used to raid the Houston offices of Michael Jackson's personal doctor was unsealed today, offering up what has been speculated for weeks: "lethal levels" of anesthetic propofol killed the pop star."
  • "Here's how crazy it got: The L.A. County Coroner's office took Jackson's medical records from Dr. Arnold Klein last week. Law enforcement sources tell us, Klein used the name Omar Arnold on some of the files. We're told inside those files, the doctor refers to Jackson by his real name."
  • "According to the affidavit, records show Dr. Klein self-prescribed 27 times from March, 2006 through May, 2009. The prescriptions include "the medications hydrocodone (Vicodin), modafinil (Provigil), diazepam (Valium), and injectable midazolam (Versed). The prescriptions were filled at Mickey Fine Pharmacy in Beverly Hills. According to California law, "No person shall prescribe, administer, or furnish a controlled substance for himself."
  • "In legal papers obtained by TMZ, Murray's legal team claims Klein fueled MJ's drug dependency by giving him scores of Demerol injections in the months prior to his death.  TMZ broke the story ... in the 3 months before Jackson died, Dr. Klein gave MJ 51 Demerol injections. The docs claim, "Due to Mr. Klein's actions, Mr. Jackson became physiologically and psychologically dependent on Demerol." 

Arnold Klein Jackson Estate Creditors Claim

  • "Astonishingly, in the document obtained by TMZ, Klein claims to have performed 179 procedures on the singer in the three months prior to his death. Klein claims the Jackson estate owes him $48,522.89 for services performed between March 23 2009 through June 22 2009 -- just three days before Jackson's death."
http://www.tmz.com/2009/10/28/arnie-klein-goes-after-jackson-estate/
____________________________

 Scene 6 1/2 Arnie Goes Bust:

X1:

Now what I find odd here is that after Michael's passing Dr. Klein filed for bankruptcy. Just what did the bulk of his business as a doctor consist of? Is it possible that he had core patients which he billed in regular intervals which made up the majority of his revenue? His excuse for his bankruptcy filing is that someone embezzled money from his bank accounts.



Now I don't know about you however the timing seems out of whack.  Not just that anyone associated with Michael which was a leech seems to have befallen a serious fate. They no longer have Michael to support them anymore and many of them are doomed financially! Then you have some associates of Michael which are not bad people however for what they knew they are no longer around to speak about it. Perhaps Ole' Arnie was using something for medicinal purposes which clouded his judgement when he decided to give Michael Demerol! Please give his shirt a once over and tell me what you think.



Arnold Klein Bankrupcy Voluntary
  •  "Klein filed for Chapter 11 at the Central California Court as a ‘Single Debtor' on January 20, 2011, listing his medical office on 435 North Roxbury Drive in Beverly Hills where Jackson was a frequent visitor. According to the court papers obtained by RadarOnline.com, Klein filed as an "individual" and he checked the box listing the number of his creditors as being between "1 and 49". It also lists his assets as being between "$0 and $50,000" and estimates his liabilities as being between "$1,000,001 and $10 million". According to the bankruptcy filing, the list of creditors holding the 20 largest unsecured claims against Dr. Klein amounts to $3,518,584. The biggest accumulative debts against Dr. Klein was with City National Bank totaling some $2,695,150 in credit lines and unpaid mortgage loans. In the bankruptcy filing it reveals that Klein owes American Express $79,493 in credit card fees, Bank Of America $79,852 in credit card and banking fees, Chase $17,579 in credit card fees and $51,857 with Citibank in credit card fees. In addition, Klein owes a Dr. David Rish $115,000 and the IRS some $127,000 in unpaid taxes, plus $103,392 to medical firm Allergen for unpaid medical supplies."
Arnie Goes Bust Radar Online

  • "Michael Jackson's doctor and longtime confidante,  Dr. Arnie Klein -- one of the most successful docs in Bev Hills -- has filed for bankruptcy ... TMZ has learned."
TMZ Explains How Arnie Went Bust
  • "Klein -- a dermatologist with an enormous celebrity clientele including Cher, Elizabeth Taylor and Dolly Parton  -- owes $80,000 to American Express, $127,000 to the IRS, nearly $2.6 million to City National Bank for a mortgage, $50,000 to one of his lawyers, $20,000 to the landlord of his office building, and $115,000 to Dr. David Rish, the doc who shares office space with Klein. Klein, who also owes nearly a quarter of a million bucks to medical suppliers, filed for Chapter 11 last Thursday."
TMZ Explains How Arnie Went Bust

Arnie Prooves He Got His Groove Back

  • "Dr. Arnie Klein -- Michael Jackson's former dermatologist -- was evacuated from his L.A. area home this morning after a fire broke out in the kitchen."Emergency vehicles responded to the blaze and evacuated 4 people from the home. Arnie was removed from the house in a stretcher and placed into a waiting ambulance.
TMZ How Arnie Got His Groove Back
  • "In the original bankruptcy petition filed in January, Dr. Klein claimed to have $3.5 million in debt, and estimated his assets to be worth $0 - $50,000. However, newly filed documents obtained exclusively by RadarOnline.com reveal Dr. Klein actually has millions of dollars in assets - $7,563,600 to be exact! Listed among his assets are three California properties: one in Los Angeles, another in Laguna Beach and yet another in Palm Springs. According to court documents, Klein's Los Angeles home -- which was gutted by fire in November 2010 -- is worth $9 million and holds $20,000 worth of gym equipment. The home was also said to be in default in October 2010, and Klein lost $1.5 million in artwork, furniture, and other items in the fire, which was covered by insurance. Dr. Klein's Laguna Beach home is valued at $12 million and the home in Palm Springs at $1.9 million. What is in those homes may surprise you. The Beverly Hills dermatologist is an avid art collector with hundreds of pieces totaling a value of $7.2 million!The collection includes Baccarat, Waterford and Lalique crystal as well as various pieces by Picasso, Gaugin, Cindy Sherman, David Hockney, bronzes by Robert Graham, photographs by Herb Ritts and numerous pieces by Andy Warhol, including the famed Marilyn Monroe - and more. In addition to his homes and extensive art collection, Dr. Klein owns many vehicles including a $170,000 2001 Ferrari 360 Modena, a $130,000 2005 Bentley GT, a $36,000 2008 Cadillac Escalade, He also owns a $4,000 2006 Honda Pilot and a $2,500 2002 Chrysler Gem.And despite his stated income of $30,000 a month, Dr. Klein has acquired a great deal of debt. The doctor owes almost $3 million to City National Bank, $100,000 to the drug company Allergen, $157,000 to the IRS, $80,000 to American Express and another $80,000 to Bank of America. The documents claim Dr. Klein has paid $30,000 to American Express and $47,000 to a law firm."
How Arnie Got His Groove Back Radar Online
____________________________

Scene 7~Evaluating The Evidence & Plausibility And Conclusions

X1:

Drawing A Conclusion
I fully intend to evaluate this entire banquet of ambiguous lies we the general public at large have been fed for a period of almost two years now. Out of the tall tale of discrepancies, falsehood, and blatant lies, there are a few notable issues which are consistently tantamount. These issues are at the forefront of this entire tragedy.

For starters, we have lost the world's greatest entertainer, an important person, an integral part of our historic legacy. Secondly, this has been a travesty of our justice system--a mockery of sorts if you will--a kangaroo system full of grand spectacle, embarrassment, and corruption. No embellishment is required for us to comprehend the damage which has been done here.

My goodness, how do we begin to repair this damage? We cannot bring Michael back. We can however fix what is the proverbial straw which broke the camel's back. We may also proceed by addressing our findings and exposing factual information. We may repair this by taking responsibility for the officials we elect for public offices--which draft these policies, this legislation, and ratify these laws in the first place.
  • "What are the odds of anyone of us getting someone in political offices who don't have any blood ties or associations?  What we are looking at here in the 22nd century is political recycling of world leaders and candidates.  If you are wondering why things are remaining the same in any country please look to its leaders.  Look and see how associated they are with one another.  How can you present an objective view if you are of the same mold and have been taught the same political concepts.  How can this be when you cannot get anyone other than those of a certain blood line out of politics to usher in the change of new and fresh politicians?" 
http://insanity-x-livesx1.blogspot.com/2011/02/new-world-order-capitalism-michaels.html


Below is a copy of Michael's autopsy. I am not going to go into this huge spiel regarding its content. We all know what is contained in this report. What I am going to do here is just list the medications which were contained therein. I cannot state for the record if the content below with the exception of the official report (s) is/are what transpired. What I can state for the record is that everything which you are about to be made aware of is 100% factual! These methods exist and thus it is important to show that they do.

If we are seeking the truth we have to take a good hard look at what is possible. The truth can sometimes be a bitter pill to swallow. While being vehement and crystal clear--this is plausible below. This is factual content. I only ask one thing--that you keep an open mind while evaluating the information which I am about to provide below. For the rest of this section I will allow the research to do the talking for itself. You may draw your own conclusions. If you are familiar with these drugs and their side effects you may bypass the drug listing/interaction section and proceed to the next section. You will know what it is when you get there if you are familiar with these drugs.
Michael Jackson Coroners Report-Autopsy


Here is a compiled PDF File listing of all of the drug interactions caused by these various pharmaceuticals below:
Pharmaceutical List Side Effects & Warnings
____________________________


Clonazepam:
  • is used alone or in combination with other medications to control certain types of seizures. It is also used to relieve panic attacks (sudden, unexpected attacks of extreme fear and worry about these attacks). Clonazepam is in a class of medications called benzodiazepines. It works by decreasing abnormal electrical activity in the brain.
Warnings:
  • tell your doctor and pharmacist if you are allergic to clonazepam, other benzodiazepines such as alprazolam (Xanax), chlordiazepoxide (Librium, in Limbitrol), clorazepate (Gen-Xene, Tranxene), diazepam (Valium), estazolam, flurazepam (Dalmane), lorazepam (Ativan), midazolam (Versed), oxazepam, temazepam (Restoril), triazolam (Halcion), or any other medications.
  • Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Pacerone); certain antibiotics such as clarithromycin (Biaxin, in Prevpac), erythromycin (Erythrocin, E-mycin), and troleandomycin (TAO) (not available in the US); antidepressants; certain antifungal medications such as itraconazole (Sporanox) and ketoconazole (Nizoral); antihistamines; certain calcium channel blockers such as diltiazem (Cardizem, Dilacor, Tiazac, others) and verapamil (Calan, Isoptin, Verelan); cimetidine (Tagamet); HIV protease inhibitors including indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir, in Kaletra); medications for anxiety, colds or allergies, mental illness, or pain; other medications for seizures such as carbamazepine (Tegretol), phenobarbital (Luminal, Solfoton), phenytoin (Dilantin), or valproic acid (Depakene, Depakote); muscle relaxants; nefazodone; rifampin (Rifadin, Rimactane); sedatives; certain selective serotonin reuptake inhibitors (SSRIs) such as fluvoxamine (Luvox); other sleeping pills; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Tell your doctor if you drink or have ever drunk large amounts of alcohol, use or have ever used street drugs or have overused prescription medications. Also tell your doctor if you have or have ever had lung or kidney disease.
Side Effects:
  • drowsiness
  • dizziness
  • unsteadiness
  • problems with coordination
  • difficulty thinking or remembering
  • increased saliva
  • muscle or joint pain
  • frequent urination
  • blurred vision
  • changes in sex drive or ability
  • Some side effects can be serious. If you experience any of these symptoms call your doctor immediately:
  • rash
  • hives
  • swelling of the eyes, face, lips, tongue, or throat
  • difficulty breathing or swallowing
  • hoarseness
  • difficulty breathing
  • is used to relieve anxiety, muscle spasms, and seizures and to control agitation caused by alcohol withdrawal. Tell your doctor and pharmacist if you are allergic to diazepam, alprazolam (Xanax), chlordiazepoxide (Librium, Librax), clonazepam (Klonopin), clorazepate (Tranxene), estazolam (ProSom), flurazepam (Dalmane), lorazepam (Ativan), oxazepam (Serax), prazepam (Centrax), temazepam (Restoril), triazolam (Halcion), or any other drugs. Tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially antihistamines; cimetidine (Tagamet); digoxin (Lanoxin); disulfiram (Antabuse); fluoxetine (Prozac); isoniazid (INH, Laniazid, Nydrazid); ketoconazole (Nizoral); levodopa (Larodopa, Sinemet); medications for depression, seizures, pain, Parkinson's disease, asthma, colds, or allergies; metoprolol (Lopressor, Toprol XL); muscle relaxants; oral contraceptives; probenecid (Benemid); propoxyphene (Darvon); propranolol (Inderal); ranitidine (Zantac); rifampin (Rifadin); sedatives; sleeping pills; theophylline (Theo-Dur); tranquilizers; valproic acid (Depakene); and vitamins. These medications may add to the drowsiness caused by diazepam.  If you use antacids, take diazepam first, then wait 1 hour before taking the antacid. Tell your doctor if you have or have ever had glaucoma; seizures; or lung, heart, or liver disease.
Side Effects:
  • drowsiness 
  • dizziness 
  • tiredness 
  • weakness 
  • dry mouth 
  • diarrhea 
  • nausea 
  • changes in appetite 
  • restlessness or excitement 
  • constipation 
  • difficulty urinating 
  • frequent urination 
  • blurred vision 
  • changes in sex drive or ability
Tell your doctor if any of these symptoms are severe or do not go away: 
  • restlessness or excitement
  • constipation
  • difficulty urinating
  • frequent urination
  • blurred vision
  • changes in sex drive or ability
If you experience any of the following symptoms, call your doctor immediately: 
  • seizures 
  • shuffling walk 
  • persistent, fine tremor or inability to sit still 
  • fever 
  • difficulty breathing or swallowing 
  • severe skin rash 
  • yellowing of the skin or eyes 
  • irregular heartbeat
  • Tamsulosin is used in men to treat the symptoms of an enlarged prostate (benign prostatic hyperplasia or BPH) which include difficulty urinating (hesitation, dribbling, weak stream, and incomplete bladder emptying), painful urination, and urinary frequency and urgency. Tamsulosin is in a class of medications called alpha blockers. It works by relaxing the muscles in the prostate and bladder so that urine can flow easily.

Warnings:
  • Tell your doctor and pharmacist if you are allergic to tamsulosin, sulfa medications, or any other medications. Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements and herbal products you are taking or plan to take. Be sure to mention any of the following: other alpha blocker medications such as alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), and terazosin (Hytrin); anticoagulants ('blood thinners') such as warfarin (Coumadin); cimetidine (Tagamet); and medications for erectile dysfunction (ED) such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra); Your doctor may need to change the doses of your medications or monitor you more carefully for side effects. 
  • You should know that tamsulosin may cause dizziness, lightheadedness, a spinning sensation, and fainting, especially when you get up too quickly from a lying position. This is more common when you first start taking tamsulosin or after your dose is increased. To help avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up. Call your doctor if these symptoms are severe or do not go away.
Side Effects:
  • sleepiness
  • difficulty falling asleep or staying asleep
  • weakness
  • back pain
  • diarrhea
  • runny or stuffy nose
  • pain or pressure in the face
  • sore throat, cough, fever, chills, or other signs of infection
  • blurred vision
  • difficulty ejaculating

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately: 

  • painful erection of the penis that lasts for hours:
  • rash
  • itching
  • hives
  • swelling of the eyes, face, tongue, lips, throat, arms, hands, feet, ankles, or lower legs
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001025

Lidocaine
HCI:
http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=22332
  • Lidocaine hydrochloride injection administered intravenously or intramuscularly, is specifically indicated in the acute management of ventricular arrhythmias such as those occurring in relation to acute myocardial infarction, or during cardiac manipulation, such as cardiac surgery.
Warnings:
  • IN ORDER TO MANAGE POSSIBLE ADVERSE REACTIONS, RESUSCITATIVE EQUIPMENT, OXYGEN AND OTHER RESUSCITATIVE DRUGS SHOULD BE IMMEDIATELY AVAILABLE WHEN LIDOCAINE HYDROCHLORIDE INJECTION IS USED. THE 10% AND 20% CONCENTRATED SOLUTIONS MUST NOT BE INJECTED UNDILUTED. See DOSAGE AND ADMINISTRATION.
  • Systemic toxicity may result in manifestations of central nervous system depression (sedation) or irritability (twitching), which may progress to frank convulsions accompanied by respiratory depression and/or arrest. Early recognition of premonitory signs, assurance of adequate oxygenation and, where necessary, establishment of artificial airway with ventilatory support are essential to management of this problem. Should convulsions persist despite ventilatory therapy with oxygen, small increments of anticonvulsant drugs may be used intravenously. Examples of such agents include benzodiazepines (e.g., diazepam), ultrashort-acting barbiturates (e.g., thiopental or thiamylal) or a short-acting barbiturate (e.g., pentobarbital or secobarbital). If the patient is under anesthesia, a short-acting muscle relaxant (e.g., succinylcholine) may be used. Longer acting drugs should be used only when recurrent convulsions are evidenced. Should circulatory depression occur, vasopressors may be used. Constant electrocardiographic monitoring is essential to the proper administration of lidocaine hydrochloride. Signs of excessive depression of cardiac electrical activity such as sinus node dysfunction, prolongation of the P-R interval and QRS complex or the appearance or aggravation of arrhythmias, should be followed by flow adjustment and, if necessary, prompt cessation of the intravenous infusion of this agent. Occasionally, acceleration of ventricular rate may occur when lidocaine hydrochloride is administered to patients with atrial flutter or fibrillation.
Side Effects:
  • Adverse experiences following the administration of lidocaine are similar in nature to those observed with other amide local anesthetic agents. Adverse experiences may result from high plasma levels caused by excessive dosage or may result from a hypersensitivity, idiosyncrasy or diminished tolerance on the part of the patient. Serious adverse experiences are generally systemic in nature. The following types are those most commonly reported. The adverse experiences under Central Nervous System and Cardiovascular System are listed, in general, in a progression from mild to severe.
  • 1. Central Nervous System: CNS reactions are excitatory and/or depressant and may be characterized by light-headedness, nervousness, apprehension, euphoria, confusion, dizziness, drowsiness, tinnitus, blurred or double vision, vomiting, sensations of heat, cold or numbness, twitching, tremors, convulsions, unconsciousness, respiratory depression and arrest. The excitatory reactions may be very brief or may not occur at all, in which case, the first manifestation of toxicity may be drowsiness, merging into unconsciousness and respiratory arrest.
  • 2. Cardiovascular System: Cardiovascular reactions are usually depressant in nature and are characterized by bradycardia, hypotension and cardiovascular collapse, which may lead to cardiac arrest.
  • 3. Allergic reactions as a result of sensitivity to lidocaine are extremely rare and, if they occur, should be managed by conventional means.
  • 4. Neurologic: There have been reported cases of permanent injury to extraocular muscles requiring surgical repair following retrobulbar administration.

  • is used to treat depression. Trazodone is in a class of medications called serotonin modulators. It works by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balance.
Warnings:
  • Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin); antidepressants, antifungal medications such as fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral); cimetidine (Tagamet); clarithromycin (Biaxin, Prevpac); cyclosporine (Neoral, Sandimmune); danazol (Danocrine); delaviridine (Rescriptor); dexamethasone (Decadron); digoxin (Digitek, Lanoxin, Lanoxicaps); diltiazem (Cardizem, Dilacor, Tiazac); erythromycin (E.E.S., E-Mycin, Erythrocin); HIV protease inhibitors such as indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), and saquinavir (Fortovase, Invirase); isoniazid (INH, Nydrazid); medications for allergies, cough or colds; medications for anxiety, high blood pressure, irregular heartbeat, mental illness or pain; medication for seizures such as carbamazepine (Tegretol), ethosuximide (Zarontin), phenobarbital (Luminal, Solfoton), and phenytoin (Dilantin); metronidazole (Flagyl); muscle relaxants; nefazodone; oral contraceptives (birth control pills); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane); sedatives; selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac, Sarafem) and fluvoxamine (Luvox); sleeping pills; tranquilizers; troleandomycin (TAO); verapamil (Calan, Isoptin, Verelan); or zafirlukast (Accolate). Also, tell your doctor or pharmacist if you are taking the following medications, called MAO inhibitors, or if you have stopped taking them within the past 2 weeks: isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate). 
  • Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin); antidepressants, antifungal medications such as fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral); cimetidine (Tagamet); clarithromycin (Biaxin, Prevpac); cyclosporine (Neoral, Sandimmune); danazol (Danocrine); delaviridine (Rescriptor); dexamethasone (Decadron); digoxin (Digitek, Lanoxin, Lanoxicaps); diltiazem (Cardizem, Dilacor, Tiazac); erythromycin (E.E.S., E-Mycin, Erythrocin); HIV protease inhibitors such as indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), and saquinavir (Fortovase, Invirase); isoniazid (INH, Nydrazid); medications for allergies, cough or colds; medications for anxiety, high blood pressure, irregular heartbeat, mental illness or pain; medication for seizures such as carbamazepine (Tegretol), ethosuximide (Zarontin), phenobarbital (Luminal, Solfoton), and phenytoin (Dilantin); metronidazole (Flagyl); muscle relaxants; nefazodone; oral contraceptives (birth control pills); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane); sedatives; selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac, Sarafem) and fluvoxamine (Luvox); sleeping pills; tranquilizers; troleandomycin (TAO); verapamil (Calan, Isoptin, Verelan); or zafirlukast (Accolate). Also, tell your doctor or pharmacist if you are taking the following medications, called MAO inhibitors, or if you have stopped taking them within the past 2 weeks: isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. You should know that trazodone may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
Side Effects:
  • headache or heaviness in head
  • nausea
  • vomiting
  • bad taste in mouth
  • stomach pain
  • diarrhea
  • constipation
  • changes in appetite or weight
  • weakness or tiredness
  • nervousness
  • decreased ability to concentrate or remember things
  • confusion
  • nightmares
  • muscle pain
  • dry mouth
  • sweating
  • blurred vision
  • tired, red, or itchy eyes
  • ringing in ears
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000530

Propofol (See PDF File):


Diprivan Propofol
 

Midazolam:
  • Important Warning: Midazolam may cause serious or life-threatening breathing problems such as shallow, slowed, or temporarily stopped breathing. Your child should only receive this medication in a hospital or doctor's office that has the equipment that is needed to monitor his or her heart and lungs and to provide life-saving medical treatment quickly if his or her breathing slows or stops. Your child's doctor or nurse will watch your child closely after he or she receives this medication to make sure that he or she is breathing properly. Tell your child's doctor if your child has a severe infection or if he or she has or has ever had any airway or breathing problems or heart or lung disease. Tell your child's doctor and pharmacist if your child is taking any of the following medications: antidepressants; barbiturates such as secobarbital (Seconal); droperidol (Inapsine); medications for anxiety, mental illness, or seizures; narcotic medications for pain such as fentanyl (Actiq, Duragesic, Sublimaze, others), morphine (Avinza, Kadian, MS Contin, others), and meperidine (Demerol); sedatives; sleeping pills; or tranquilizers.
Warnings:
  • Tell your child's doctor and pharmacist if he or she is allergic to midazolam, any other medications, or cherries. Tell your child's doctor if your child is taking certain medications for human immunodeficiency virus (HIV) including amprenavir (Agenerase), atazanavir (Reyataz), darunavir (Prezista), delavirdine (Rescriptor), efavirenz (Sustiva, in Atripla), fosamprenavir (Lexiva), indinavir (Crixivan),lopinavir (in Kaletra), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), saquinavir (Invirase), and tipranavir (Aptivus). Your child's doctor may decide not to give midazolam to your child if he or she is taking one or more of these medications.
  • Tell your child's doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements your child is taking or plans to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: amiodarone (Cordarone, Pacerone); aminophylline (Truphylline); antifungals such as fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral); certain calcium channel blockers such as diltiazem (Cartia, Cardizem, Tiazac, others) and verapamil (Calan, Isoptin, Verelan, others); cimetidine (Tagamet); clarithromycin (Biaxin); dalfopristin-quinupristin (Synercid); erythromycin (E-mycin, E.E.S.); fluvoxamine (Luvox); certain medications for seizures such as carbamazepine (Tegretol), phenobarbital, and phenytoin (Dilantin); methylphenidate (Concerta, Metadate, Ritalin, others); nefazodone; ranitidine (Zantac); rifabutin (Mycobutin); and rifampin (Rifadin, Rimactane). Your child's doctor may need to change the doses of your child's medications or monitor your child carefully for side effects. Many other medications may also interact with midazolam, so be sure to tell your child's doctor about all the medications your child is taking, even those that do not appear on this list.
  • Tell your child's doctor what herbal products your child is taking, especially St. John's wort. Tell your child's doctor if your child has glaucoma. Your child's doctor may decide not to give your child midazolam. Tell your child's doctor if your child has or has ever had kidney or liver disease. Tell your child's doctor if your child is or may be pregnant, or is breast-feeding.
Side Effects:
  • You should know that midazolam may make your child very drowsy and may affect his or her memory, thinking, and movements. Do not allow your child to ride a bicycle, drive a car, or do other activities that require him or her to be fully alert for at least 24 hours after receiving midazolam and until the effects of the medication have worn off. Watch your child carefully to be sure that he or she does not fall while walking during this time. You should know that alcohol can make the side effects of midazolam worse.
Midazolam may cause side effects. Tell your child's doctor if any of these symptoms are severe or do not go away:
  • nausea
  • vomiting
  • rash
Some side effects can be serious. If your child experiences any of these symptoms, call his or her doctor immediately:
  • agitation
  • restlessness
  • uncontrollable shaking of a part of the body
  • stiffening and jerking of the arms and legs
  • aggression
  • slow or irregular heartbeat
  • Midazolam may cause other side effects. Call your child's doctor if your child has any unusual problems while taking this medication.
  • Complete or partial reversal of sedative effects of benzodiazepines where general anesthesia induced or maintained with benzodiazepines, where sedation produced with benzodiazepines for diagnostic or therapeutic procedures, and for the management of benzodiazepine overdose.
Dosage and Administration:

Reversal of Conscious Sedation or in General Anesthesia Adults
  • IV 0.2 mg over 15 sec. If desired level of consciousness is not achieved in 45 sec, additional 0.2 mg doses can be administered at 60 sec intervals (max, 1 mg). In event of resedation, repeat doses (0.2 mg/min to max 1 mg) at 20 min intervals as needed (max, 3 mg/h).
  • Management of Suspected Benzodiazepine Overdose
  • Adults
  • IV 0.2 mg over 30 sec. If desired level of consciousness is not achieved in 30 sec, an additional dose of 0.3 mg over 30 sec can be administered. Further doses of 0.5 mg over 30 sec can be administered at 1 min intervals as needed (max, 3 mg).
Side Effects:
  • Toxic effects of other drugs taken in toxic doses may emerge with reversal of benzodiazepine effect.
http://www.drugs.com/ppa/flumazenil.html

Lorzepam:

  • is used to relieve anxiety. Lorazepam is in a class of medications called benzodiazepines. It works by slowing activity in the brain to allow for relaxation.
Other uses for this medicine:
  • Lorazepam is also used to treat irritable bowel syndrome, epilepsy, insomnia, and nausea and vomiting from cancer treatment and to control agitation caused by alcohol withdrawal. Talk to your doctor about the possible risks of using this medication for your condition. This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
Warnings:
  • Tell your doctor and pharmacist if you are allergic to lorazepam, alprazolam (Xanax), chlordiazepoxide (Librium, Librax), clonazepam (Klonopin), clorazepate (Tranxene), diazepam (Valium), estazolam (ProSom), flurazepam (Dalmane), oxazepam (Serax), prazepam (Centrax), temazepam (Restoril), triazolam (Halcion), any other medications, or any of the ingredients in lorazepam tablets or concentrate. Ask your doctor or pharmacist for a list of the ingredients.
  • Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antihistamines; digoxin (Lanoxin); levodopa (Larodopa, Sinemet); medications for depression, seizures, pain, Parkinson's disease, asthma, colds, or allergies; muscle relaxants; oral contraceptives; probenecid (Benemid); rifampin (Rifadin); sedatives; sleeping pills; theophylline (Theo-Dur); tranquilizers; and valproic acid (Depakene).Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:
  • shuffling walk
  • persistent, fine tremor or inability to sit still
  • fever
  • difficulty breathing or swallowing
  • severe skin rash
  • yellowing of the skin or eyes
  • irregular heartbeat
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000560

Ephedrine Caffeine, Aspirin
:
  • The ECA stack is a drug combination used in weight loss and as a stimulant. ECA is an acronym for ephedrine, caffeine, and aspirin. Dietary supplements based on or including elements of ECA were popular through the 1990s but the marketing of ephedra- or ephedrine-containing stimulant combinations for weight loss and bodybuilding is now restricted or illegal in the United States and Canada due to reports of heart attack, stroke, and death associated with these supplements.
Warnings:
  • "Natural" supplements that contain ephedra (aka Ma Huang) as an ephedrine substitute have been linked to cases of heart attack, stroke, and death in healthy young adults even when taken at the labeled dosage. Evidence of serious harm is based only on self-reports of uncontrolled use by supplement users; when EC has been used as medically prescribed or in controlled studies, evidence of cardiovascular risk has not been found.
  • A 2003 meta-analysis of all available studies and case reports concluded that "ephedrine- and ephedra-containing dietary supplements have harms in terms of a 2- to 3-fold increase in psychiatric symptoms, autonomic symptoms, upper gastrointestinal symptoms, and heart palpitations. More serious adverse effects from ephedra use cannot be excluded at a rate less than 1.0 per thousand, and case reports raise the possibility that a causal relationship with serious adverse events may exist."
Legal Status:
  • Due to deaths linked to ephedra-containing dietary supplements and the potential use of ephedrine as a precursor in illegal methamphetamine manufacture, many countries have taken steps to regulate these products.
Status in The United States:
  • In the United States, it is illegal to market products containing ephedrine or ephedra alkaloids as a dietary supplement. In 2004, ephedra, a botanical source of ephedrine alkaloids, was banned by the U.S. Food and Drug Administration due to serious safety concerns, injuries, and deaths linked to ephedra-containing supplements. However, ephedrine itself has never been illegal in the United States and is currently available over-the-counter. Reporting requirements and quantity limitations vary by state.
http://en.wikipedia.org/wiki/ECA_stack

Zanaflex:

  • is used to relieve the spasms and increased muscle tone caused by multiple sclerosis (MS, a disease in which the nerves do not function properly and patients may experience weakness, numbness, loss of muscle coordination and problems with vision, speech, and bladder control), stroke, or brain or spinal injury. Tizanidine is in a class of medications called skeletal muscle relaxants. It works by slowing action in the brain and nervous system to allow the muscles to relax.
Warnings:
  • Tell your doctor and pharmacist if you are allergic to tizanidine or any other medications. Tell your doctor if you are taking ciprofloxacin (Cipro) or fluvoxamine. Your doctor will probably tell you not to take tizanidine if you are taking either of these medications.
  • Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: acyclovir (Zovirax); amiodarone (Cordarone, Pacerone); baclofen; cimetidine (Tagamet); clonidine (Catapres, Catapres-TTS); dantrolene (Dantrium); diazepam (Valium); famotidine (Pepcid, Pepcid AC); medications for anxiety, seizures, or high blood pressure; mexiletine (Mexitil); oral contraceptives (birth control pills); propafenone (Rythmol); fluoroquinolones such as gemifloxacin (Factive), levofloxacin (Levaquin), moxifloxacin (Avelox), norfloxacin (Noroxin), and ofloxacin (Floxin); ticlopidine (Ticlid); sedatives; sleeping pills; tranquilizers; verapamil (Calan, Covera, Isoptin, Verelan); and zileuton (Zyflo). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Other medications may also interact with tizanidine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
  • Tell your doctor if you have or have ever had kidney or liver disease. Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking tizanidine, call your doctor. You should know that this medication may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you. Remember that alcohol can add to the drowsiness caused by this medication.
  • You should know that tizanidine may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking tizanidine. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up. Tizanidine can decrease muscle tone, so be careful when walking or doing other activities where you rely on your muscle tone to help with your posture or balance.
Side Effects:
  • dizziness
  • drowsiness
  • weakness
  • nervousness
  • depression
  • vomiting
  • tingling sensation in the arms, legs, hands, and feet
  • dry mouth
  • constipation
  • diarrhea
  • stomach pain
  • heartburn
  • increased muscle spasms
  • back pain
  • rash
  • sweating
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
  • nausea
  • extreme tiredness
  • unusual bleeding or bruising
  • lack of energy
  • loss of appetite
  • pain in the upper right part of the stomach
  • yellowing of the skin or eyes
  • unexplained flu-like symptoms
  • seeing things or hearing voices that do not exist
  • slow heartbeat
  • changes in vision
  • Tizanidine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000106

Prednisone:

  • Prednisone is used alone or with other medications to treat the symptoms of low corticosteroid levels (lack of certain substances that are usually produced by the body and are needed for normal body functioning). Prednisone is also used to treat other conditions in patients with normal corticosteroid levels. These conditions include certain types of arthritis; severe allergic reactions; multiple sclerosis (a disease in which the nerves do not function properly); lupus (a disease in which the body attacks many of its own organs); and certain conditions that affect the lungs, skin, eyes, kidneys blood, thyroid, stomach, and intestines. Prednisone is also sometimes used to treat the symptoms of certain types of cancer. Prednisone is in a class of medications called corticosteroids. It works to treat patients with low levels of corticosteroids by replacing steroids that are normally produced naturally by the body. It works to treat other conditions by reducing swelling and redness and by changing the way the immune system works.
Warnings:
  • Tell your doctor and pharmacist if you are allergic to prednisone, any other medications, or any of the inactive ingredients in prednisone tablets or solutions. Ask your doctor or pharmacist for a list of the inactive ingredients.
  • Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Pacerone); anticoagulants ('blood thinners') such as warfarin (Coumadin); certain antifungals such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral) and voriconazole (Vfend);aprepitant (Emend); aspirin; carbamazepine (Carbatrol, Epitol, Tegretol); cimetidine (Tagamet); clarithromycin (Biaxin, in Prevpak); cyclosporine (Neoral, Sandimmune); delavirdine (Rescriptor); diltiazem (Cardizem, Dilacor, Tiazac, others); dexamethasone (Decadron, Dexpak); diuretics ('water pills'); efavirenz (Sustiva); fluoxetine (Prozac, Sarafem); fluvoxamine (Luvox); griseofulvin (Fulvicin, Grifulvin, Gris-PEG); HIV protease inhibitors including atazanavir (Reyataz), indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Fortovase, Invirase); hormonal contraceptives (birth control pills, patches, rings, implants, and injections); lovastatin (Altocor, Mevacor); medications for diabetes; nefazodone; nevirapine (Viramune); phenobarbital; phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, in Rifamate); sertraline (Zoloft); troleandomycin (TAO); verapamil (Calan, Covera, Isoptin, Verelan); and zafirlukast (Accolate).Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Tell your doctor what herbal products you are taking or plan to take, especially St. John's wort.

  • Tell your doctor if you have an eye infection now or have ever had eye infections that come and go and if you have or have ever had threadworms (a type of worm that can live inside the body); diabetes; high blood pressure; emotional problems; mental illness; myasthenia gravis (a condition in which the muscles become weak); osteoporosis (condition in which the bones become weak and fragile and can break easily); seizures; tuberculosis (TB); ulcers; or liver, kidney, intestinal, heart, or thyroid disease.

  • Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking prednisone, call your doctor.

  • If you are having surgery, including dental surgery, or need emergency medical treatment, tell the doctor, dentist, or medical staff that you are taking or have recently stopped taking prednisone. You should carry a card or wear a bracelet with this information in case you are unable to speak in a medical emergency.

  • Do not have any vaccinations (shots to prevent diseases) without talking to your doctor.

  • You should know that prednisone may decrease your ability to fight infection and may prevent you from developing symptoms if you get an infection. Stay away from people who are sick and wash your hands often while you are taking this medication. Be sure to avoid people who have chicken pox or measles. Call your doctor immediately if you think you may have been around someone who had chicken pox or measles.
Side Effects:
  • headache
  • dizziness
  • difficulty falling asleep or staying asleep
  • inappropriate happiness
  • extreme changes in mood
  • changes in personality
  • bulging eyes
  • acne
  • thin, fragile skin
  • red or purple blotches or lines under the skin
  • slowed healing of cuts and bruises
  • increased hair growth
  • changes in the way fat is spread around the body
  • extreme tiredness
  • weak muscles
  • irregular or absent menstrual periods
  • decreased sexual desire
  • heartburn
  • increased sweating
  • Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:
  • vision problems
  • eye pain, redness, or tearing
  • sore throat, fever, chills, cough, or other signs of infection
  • seizures
  • depression
  • loss of contact with reality
  • confusion
  • muscle twitching or tightening
  • shaking of the hands that you cannot control
  • numbness, burning, or tingling in the face, arms, legs, feet, or hands
  • upset stomach
  • vomiting
  • lightheadedness
  • irregular heartbeat
  • sudden weight gain
  • shortness of breath, especially during the night
  • dry, hacking cough
  • swelling or pain in the stomach
  • swelling of the eyes, face, lips, tongue, throat, arms, hands, feet, ankles, or lower legs
  • difficulty breathing or swallowing
  • rash
  • hives
  • itching
  • Prednisone may slow growth and development in children. Your child's doctor will watch his or her growth carefully. Talk to your child's doctor about the risks of giving prednisone to your child. Prednisone may increase the risk that you will develop osteoporosis. Talk to your doctor about the risks of taking prednisone and about things that you can do to decrease the chance that you will develop osteoporosis. Some patients who took prednisone or similar medications developed a type of cancer called Kaposi's sarcoma. Talk to your doctor about the risks of taking prednisone.Prednisone may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000091#a601102-how

Amoxicillin:

  • Amoxicillin is used to treat certain infections caused by bacteria, such as pneumonia; bronchitis; gonorrhea; and infections of the ears, nose, throat, urinary tract, and skin. It is also used in combination with other medications to eliminate H. pylori, a bacteria that causes ulcers. Amoxicillin is in a class of medications called penicillin-like antibiotics. It works by stopping the growth of bacteria. Antibiotics will not work for colds, flu, and other viral infections.
Warnings:
  • Tell your doctor and pharmacist if you are allergic to amoxicillin, penicillin, cephalosporins, or any other medications.Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: chloramphenicol (Chlormycetin), other antibiotics, and probenecid (Benemid). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Tell your doctor if you have or have ever had kidney disease, allergies, asthma, hay fever, hives, or phenylketonuria.
Side Effects:
  • Upset stomach
  • vomiting
  • diarrhea
Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately: 
  • severe skin rash
  • hives
  • seizures
  • yellowing of the skin or eyes
  • unusual bleeding or bruising
  • pale skin
  • excessive tiredness
  • lack of energy
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000837#a685001-how


Azithromycin:

  • is used to treat certain infections caused by bacteria, such as bronchitis; pneumonia; sexually transmitted diseases (STD); and infections of the ears, lungs, skin, and throat. Azithromycin is in a class of medications called macrolide antibiotics. It works by stopping the growth of bacteria. Antibiotics will not work for colds, flu, or other viral infections.
Warnings:
  • Tell your doctor and pharmacist if you are allergic to azithromycin, clarithromycin (Biaxin), dirithromycin (Dynabac), erythromycin (E.E.S., E-Mycin, Erythrocin), or any other medications.
  • Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin); cyclosporine (Neoral, Sandimmune); digoxin (Lanoxin); dihydroergotamine (D.H.E. 45, Migranal); ergotamine (Ergomar); medications that suppress the immune system; nelfinavir (Viracept); phenytoin (Dilantin); and terfenadine (Seldane). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. If you take antacids (Mylanta, Maalox), take them 2 hours before or 4 hours after azithromycin. Tell your doctor if you have or have ever had cystic fibrosis, human immunodeficiency virus (HIV), irregular heartbeat, or kidney or liver disease.
Side Effects:
  • upset stomach
  • diarrhea
  • vomiting
  • stomach pain
  • mild skin rash
Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:
  • severe skin rash
  • hives
  • itching
  • difficulty breathing or swallowing
  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
  • hoarseness
  • yellowing of the skin or eyes
  • rapid, pounding, or irregular heartbeat
  • Azithromycin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001009#a697037-how 
___________________________
Scene Seven~Severe Poly Substance Misuse/Withdrawl States In ICU:

Research:

Abstract
  • "A safe, rapid, and effective way to detoxify patients from substance misuse is important in facilitating further treatment of their psychiatric or substance use disorder. This paper discusses the treatment of acute withdrawal from polysubstance misuse in three patients in the intensive care unit setting using combined sedation with a benzodiazepine, lorazepam, and a general anaesthetic, propofol. Lorazepam alone was not effective in massive doses in these cases. The advantages and mechanism of action of using multiple agents to control refractory symptoms is discussed."
___________________________
Propofol Combined With Lorazepam for Severe Poly Substance Misuse and Withdrawal States in Intensive Care Unit
  • "Several pharmacological approaches for managing withdrawal have been suggested based on the substance used. Benzodiazepines remain the gold standard for alcohol withdrawal delirium and methadone is often used to prevent opioid withdrawal syndrome.2 Propofol, an intravenous anaesthetic agent, used for sedation in the intensive care unit is easily titrated to the effect and consciousness returns rapidly after withdrawal of the drug with minimal residual central system effects.3 The use of multiple agents acting on different neurotransmitter systems reduces the required dose and side effects of one drug while blocking the symptoms of withdrawal effectively. In this paper, we describe our experience of combination therapy with propofol and lorazepam in three patients presented to the intensive care unit with poly substance misuse and severe withdrawal symptoms, which were not controlled by large doses of lorazepam alone." 
http://emj.bmj.com/content/21/5/632.abstract
  • "Symptoms of alcohol withdrawal typically begin within 4 to 12 hours after cessation or reduction of alcohol use, peak in intensity during the second day of abstinence, and generally resolve within four to five days. Symptoms of alcohol withdrawal include tremors, autonomic dysfunction (tachycardia, tachypnoea, fever, and sweating), insomnia, restlessness, agitation, anxiety, panic attacks, and gastrointestinal upset. Fewer than 5% of patients withdrawing from alcohol progress to delirium tremens; a condition that has significant morbidity and mortality.4 Delirium tremens is a state of confusion accompanied by visual, tactile, and auditory hallucinations. Cocaine withdrawal symptoms are mild and no specific pharmacological treatment is indicated on a regular basis."
  • "Although the untreated opioid addict experiences significant anxiety and discomfort, the process itself presents no serious risks.The classic symptomatology and the typical onset and duration of symptoms of alcohol withdrawal may be modified by the concurrent misuse of other substances such as heroin and cocaine. Benzodiazepines are the mainstay of treatment for alcohol withdrawal states. Alcohol withdrawal delirium may require large doses of benzodiazepines (such as 1000 mg diazepam). There are reports in which massive doses of benzodiazepines failed to prevent or shorten the duration of DTs. Benzodiazepines bind at the GABA benzodiazepine receptor in the central nervous system and when these receptors are saturated additional drug cannot bind. These patients may tolerate these exceedingly higher doses but not necessarily benefit from them. Residual sedation and prolonged rehabilitation may increase the hospital stay in these patients because benzodiazepines are sequestrated in fat stores after high dose therapy. Propylene glycol toxicity marked by acidosis, tubular necrosis leading to acute renal failure has been reported with higher doses of lorazepam or prolonged infusion of the drug.Considering these disadvantages, there is a need for an alternate and additive drug in the treatment of these patients."
  • "Coomes et al first reported the successful use of propofol in DT in a patient refractory to massive doses of benzodiazepines.McGowan et al concluded in their case series that propofol should be considered as a therapeutic option in patients with refractory DT.8 All of their patients had improved symptom control with propofol. Benzodiazepines act only through GABA receptors. Propofol is synergistic with lorazepam at GABA receptors. In addition, propofol inhibits NMDA subtype of glutamate receptors, which explains its superiority over benzodiazepines. NMDA-receptors seem to play a central part in alcohol and other substance dependence, withdrawal states, and alcohol induced neurological disorders. The mechanism of action of propofol in opioid withdrawal states may also be related to NMDA receptors or this could just be a general anaesthetic effect."
  • "Propofol has been successfully used for sedation during rapid opioid detoxification. There is no pharmacological evidence for propofol acting at opioid receptors. In our case series, we added propofol and reduced the dose of lorazepam once we realised the resistance of symptoms to high dose lorazepam. Lorazepam and chlordiazepoxide were preferred to midazolam because of their intermediate half life and benefit in the prevention of seizures and a much more smoother withdrawal course in these patient populations with less breakthrough symptoms after short acting propofol has been stopped. Carrasco et al have shown the synergistic effects of co-administration of midazolam and propofol for sedation after coronary artery bypass surgery. Combination therapy provided safe and effective sedation with advantages over conventional regimen with propofol or midazolam administered as sole agents, such as absence of haemodynamic impairment, .68% reduction in maintenance dose, and lower pharmaceutical cost. Reduction in dose and duration of propofol infusion with combined sedation will avoid problems of long term high dose propofol sedation such as higher cost, hypertriglyceridaemia, pancreatitis, severe protracted metabolic acidosis, haemodynamic impairment and delayed seizures. Currier et al described a patient who developed alcohol withdrawal syndrome in the postoperative period after internal fixation of ankle fracture. The patient’s symptoms were not controlled by midazolam or propofol and required muscle relaxation and mechanical ventilation. The authors explained the refractoriness of withdrawal symptoms by the acute tachyphylaxis to propofol because the patient initially responded to small doses of propofol and failed to respond later on even with 1000 mg/kg/h of propofol infusion. We did not encounter propofol related complications in any of the three patients."
http://emj.bmj.com/content/21/5/632.abstract
  • "Various scales have been described to evaluate the severity of withdrawal symptoms such as the objective opiate withdrawal scale, the subjective opiate withdrawal scale,and the revised clinical institute withdrawal assessment for alcohol scale.These scales may be useful in patients with mild withdrawal symptoms in the general medical floor but were very difficult to use in ICU patients with severe symptoms requiring very deep sedation, endotracheal intubation, and Combination therapy for severe withdrawal syndromes 633 www.emjonline.com mechanical ventilation. These scales also will not be useful in patients with psychotic disorders such as case. However, we used sedation scoring, which is simple to use by our nursing staff to titrate the drugs to control the symptoms such as agitation, restlessness, hallucinations, sweating, and tremors. It was aimed to achieve symptom control with a sedation score of 2 in all the patients. None of the patients responded and sedation was deepened to score 1. All patients became awake and responding after 15–20 minutes of stopping propofol infusion. This is an advantage over the other drugs studied in the treatment of alcohol withdrawal syndrome such as flunitrazepam, chlormethiazole, haloperidol, and clonidine. Haloperidol can aggravate delirium and lower seizure threshold in these patients. In combination with benzodiazepines, the duration of mechanical ventilation may be prolonged and a small percentage of patients may develop neuroleptic malignant syndrome. Clonidine is less effective in suppressing hallucinations and may increase the cardiovascular complications. We used haloperidol in case 2 because of his psychiatric history and clonidine was used in case 3 to suppress autonomic signs."
http://emj.bmj.com/content/21/5/632.abstract
  • "In conclusion, propofol added to lorazepam is safe and effective in controlling the symptoms of acute withdrawal syndrome associated with poly substance misuse. Multimodal therapy using benzodiazepines, propofol, haloperidol, clonidine, and methadone should be tried in these patients to reduce the required dose and side effects of any individual drug. Further well controlled clinical studies are recommended with various combinations of drugs to find out an ideal cost effective regimen to treat these patients requiring ICU admission."
http://emj.bmj.com/content/21/5/632.abstracthttp://emj.bmj.com/content/21/5/632.abstract
  • "In the months leading up to his London performances, Jackson told his sister that he was on a six-month detox to prepare for his comeback, but LaToya says she had other suspicions. "Michael was being inappropriately treated by people who got him hooked on drugs,” she told the News of the World. "He had many needle marks on his neck and on his arms, and more about those will emerge in the next few weeks. But nothing has changed my mind that this was murder.”
  • “My brother had a problem with drugs, and he was in denial... There were many interventions by the family members, and I was involved in a lot of that. It was such a sad thing and it hurt so bad.”
http://hiphollywood.com/hipheadlines/2010/4/18/rebbie-jackson-on-michael-my-brother-had-a-problem-with-drug.html


________________________________________



SCENE 8 ABOVE ALL LOVE IS UNCONDITIONAL:


*This blog entry has been republished. It's original publishing date was on 7/21/10
 

 

X1:

Michael had incredible resolve in the face of adversities and obstacles. To me Michael was a fighter! *Michael just out did other humans this is where all the hate and envy came from. I feel often most times supporters and fans the like put Michael on this angelic plane as if he did not have problems.  Yes I do believe that Michael was sent to us by GOD to do work here on earth however GOD chose to send Michael to us in the form of a human being.


When Michael experienced the horrible burn accident that happened to him he required something for the pain--he had sustained third degree burns!  A part of me thinks that Michael was in pain long afterward.  I don't think that the pain he experienced from that accident ever subsided.   He again was human and as a direct result of that he formed an addiction to the pain killers that were prescribed to relieve this pain.  Michael was not exempt from experiencing an addiction to any substances because he was "Michael Jackson". 

I honestly think that it is time for supporters and fans to face reality that Michael was a human being.  He might have been a super hero to millions of people however he hurt, bled, and felt pain just like the rest of us.  It is not impossible for him to have formed an addiction to anything.  Millions of people have suffered with addictions as the direct result of pain killers which were prescribed after a very bad accident.  Why would it be impossible for Michael to have experienced this?


Michael was no exclusion and he was not perfect.  I often think that Michael was under enormous pressure!  I would like to invite someone to try and cope with everything which he was subjected to and then tell me if you would...

I am starting to think that if you say Michael was anything but angelic--you will have personal attacks coming from every which direction. It seems that some people are in a serious denial about Michael's humanity. There is also a serious denial factor transpiring regarding Michael having no exemptions from experiencing pain or problems just like the rest of us I apologize for having to be the one to destroy this illusion and fantasy world that some people are in.  It is not my intent to shatter anyone's glass house.

Did it ever occur to anyone that Michael still experienced pain and was unable to sleep as a direct result?  We are not even going to get into the various adversities which caused him pain of a different kind--which Michael had to suffer and endure.  I think Michael was the most exploited person that I have ever seen in my lifetime.  



Through out all of this exploitation that Michael was confronted with--he still got on that stage and put on one heck of a great show.  Michael was superhuman from this perspective!  Michael was a showman by trade make no mistake about it--phenomenal and riveting performances are what you got from him.  I think this is a testament to Michael's natural strength, ability, genius, endurance, and perseverance as a man. I am not singing the Michael was perfect song here.  I am singing the Michael was a great human being song here.  Michael was a human being that cared more about others than he did his own-self!





We as fans and supporters also put Michael under lots of pressure.  All those concerts flying from country to country this puts a great toll on a person.  Not only that Michael could not go out like a normal human being to the store or to explore normal things which we all take for granted.  He was consistently being mobbed and harassed by people that posed a security risk to him.  Imagine being confined to a several million dollar home most of your life and the only time you can leave your home is to perform for people. What is much worse about this is your home is nice--and it has become a virtual prison. Your are sentenced to a lifetime of virtual confinement in your wonderful and fabulous home. I am quite sure that Michael did not wish to spend every waking moment confined to his home as a recluse.




When Michael wanted to take to the world and explore real life without being noticed--he had to utilize a disguise to do it.  How about him having the ability to just be Michael??  What happened to that?  I can recall a statement that Michael made regarding how when he would go to parties how they would expect him to perform and he was there to enjoy himself and the environment.  It was like if he went to a party or any public venue a performance was expected.   


Imagine what it must be like to not have privacy or not be bothered when you just did not feel to.  I think we as fans need to consider that Michael was human and he had problems just like everyone else.  Make no mistake it took lots of resolve to be Michael! 

**However, I am still trying to figure out what is the crime regarding being human aren't we all???

-X1

Sources by Michelle Edwards:)